Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus
Joint Authors
Yang, Fangyuan
He, Yi
Zhai, Zeqing
Sun, Erwei
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by excessive inflammatory and immune responses and tissue damage.
Increasing evidence has demonstrated the important role of programmed cell death in SLE pathogenesis.
When apoptosis encounters with defective clearance, accumulated apoptotic cells lead to secondary necrosis.
Different forms of lytic cell death, including secondary necrosis after apoptosis, NETosis, necroptosis, and pyroptosis, contribute to the release of damage-associated molecular patterns (DAMPs) and autoantigens, resulting in triggering immunity and tissue damage in SLE.
However, the role of autophagy in SLE pathogenesis is in dispute.
This review briefly discusses different forms of programmed cell death pathways and lay particular emphasis on inflammatory cell death pathways such as NETosis, pyroptosis, and necroptosis and their roles in the inflammatory and immune responses in SLE.
American Psychological Association (APA)
Yang, Fangyuan& He, Yi& Zhai, Zeqing& Sun, Erwei. 2019. Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1176080
Modern Language Association (MLA)
Yang, Fangyuan…[et al.]. Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus. Journal of Immunology Research No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1176080
American Medical Association (AMA)
Yang, Fangyuan& He, Yi& Zhai, Zeqing& Sun, Erwei. Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1176080
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176080