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Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38−− Mice
Joint Authors
Li, Qi
Wu, Chenyi
Liu, Zhenlong
Zhang, Huiqing
Du, Yuna
Liu, Yuxiang
Song, Kuangyu
Shi, Qiaofa
Li, Rong
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Gram-negative bacterial sepsis accounts for up to 50% worldwide sepsis that causes hospital mortality.
Acute kidney injury (AKI), a common complication of Gram-negative bacterial sepsis, is caused by Toll-like receptor 4 (TLR4) activation.
Lipopolysaccharide (LPS) is an endotoxin in Gram-negative bacteria and is recognized specifically by TLR4, which initiates innate immune response.
Also, TLR4 signaling pathway activation is essential in response to LPS infection.
CD38 is one of the well-known regulators of innate immunity, whose dysregulation contributes to sepsis.
Many studies have proven that an attenuated Gram-positive bacterium induces sepsis in a CD38-blocking model.
However, the pathogenesis of Gram-negative bacteria-induced sepsis in a CD38−/− mouse model remains unclear.
The aim of this study is to investigate whether kidney injury is still attenuated in a LPS-induced CD38−/− sepsis model and identify the potential mechanism.
We assess the severity of kidney injury related to proinflammatory cytokine expressions (IFN-γ, TNF-α, IL-1β, and IL-6) in WT and CD38−/− mice.
Our results showed more aggravated kidney damage in CD38−/− mice than in WT mice, accompanied with an increase of proinflammatory cytokine expression.
In addition, compared with CD38−/−TLR4mut mice, we found an increase of TLR4 expression and mRNA expression of these cytokines in the kidney of CD38−/− mice, although only increased IFN-γ level was detected in the serum.
Taken together, these results demonstrated that an increased TLR4 expression in CD38−/− mice could contribute to the aggravation of AKI through boosting of the production of IFN-γ.
American Psychological Association (APA)
Li, Qi& Du, Yuna& Liu, Yuxiang& Song, Kuangyu& Shi, Qiaofa& Li, Rong…[et al.]. 2019. Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38−− Mice. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1176103
Modern Language Association (MLA)
Du, Yuna…[et al.]. Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38−− Mice. Journal of Immunology Research No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1176103
American Medical Association (AMA)
Li, Qi& Du, Yuna& Liu, Yuxiang& Song, Kuangyu& Shi, Qiaofa& Li, Rong…[et al.]. Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38−− Mice. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1176103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176103