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Preliminary Evaluation of the Safety and Immunogenicity of an Antimalarial Vaccine Candidate Modified Peptide (IMPIPS) Mixture in a Murine Model
Joint Authors
Patarroyo, Manuel A.
Patarroyo, Manuel Elkin
Lambraño, Jennifer
Curtidor, Hernando
Avendaño, Catalina
Díaz-Arévalo, Diana
Roa, Leonardo
Vanegas, Magnolia
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Malaria continues being a high-impact disease regarding public health worldwide; the WHO report for malaria in 2018 estimated that ~219 million cases occurred in 2017, mostly caused by the parasite Plasmodium falciparum.
The disease cost the lives of more than 400,000 people, mainly in Africa.
In spite of great efforts aimed at developing better prevention (i.e., a highly effective vaccine), diagnosis, and treatment methods for malaria, no efficient solution to this disease has been advanced to date.
The Fundación Instituto de Inmunología de Colombia (FIDIC) has been developing studies aimed at furthering the search for vaccine candidates for controlling P.
falciparum malaria.
However, vaccine development involves safety and immunogenicity studies regarding their formulation in animal models before proceeding to clinical studies.
The present work has thus been aimed at evaluating the safety and immunogenicity of a mixture of 23 chemically synthesised, modified peptides (immune protection-inducing protein structure (IMPIPS)) derived from different P.
falciparum proteins.
Single and repeat dose assays were thus used with male and female BALB/c mice which were immunised with the IMPIPS mixture.
It was found that single and repeat dose immunisation with the IMPIPS mixture was safe, both locally and systemically.
It was observed that the antibodies so stimulated recognised the parasite’s native proteins and inhibited merozoite invasion of red blood cells in vitro when evaluating the humoral immune response induced by the IMPIPS mixture.
Such results suggested that the IMPIPS peptide mixture could be a safe candidate to be tested during the next stage involved in developing an antimalarial vaccine, evaluating local safety, immunogenicity, and protection in a nonhuman primate model.
American Psychological Association (APA)
Lambraño, Jennifer& Curtidor, Hernando& Avendaño, Catalina& Díaz-Arévalo, Diana& Roa, Leonardo& Vanegas, Magnolia…[et al.]. 2019. Preliminary Evaluation of the Safety and Immunogenicity of an Antimalarial Vaccine Candidate Modified Peptide (IMPIPS) Mixture in a Murine Model. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1176126
Modern Language Association (MLA)
Lambraño, Jennifer…[et al.]. Preliminary Evaluation of the Safety and Immunogenicity of an Antimalarial Vaccine Candidate Modified Peptide (IMPIPS) Mixture in a Murine Model. Journal of Immunology Research No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1176126
American Medical Association (AMA)
Lambraño, Jennifer& Curtidor, Hernando& Avendaño, Catalina& Díaz-Arévalo, Diana& Roa, Leonardo& Vanegas, Magnolia…[et al.]. Preliminary Evaluation of the Safety and Immunogenicity of an Antimalarial Vaccine Candidate Modified Peptide (IMPIPS) Mixture in a Murine Model. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1176126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176126