Immunobiotics Beneficially Modulate TLR4 Signaling Triggered by Lipopolysaccharide and Reduce Hepatic Steatosis In Vitro
Joint Authors
Kim, Hojun
Kanmani, Paulraj
Ansari, AbuZar
Villena, Julio
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Hepatic inflammation and injury may result from the translocation of pathological bacteria and their proinflammatory mediators.
Probiotics attenuate hepatic diseases related to inflammation by exhibiting immunoregulatory effects.
Therefore, this study was conducted to evaluate lipid reduction and immunoregulatory potentials of probiotic bacteria in vitro.
HepG2 cells treated with total cellular fluid (TCF) of LABs reduced lipid accumulation.
Moreover, cells responded to lipopolysaccharide (LPS) by producing higher levels of IL-6, IL-8, MCP-1, and TNF-α.
TCF of LABs treatment showed remarkably diminished levels of the expression of these cytokines via modulation of the expression of TLR-negative regulators, as well as MAPK and NF-κB pathways.
Moreover, heat-killed LABs were able to diminish TGF-β, IL-1β, and IL-6 and to increase IL-10 and TLR4 levels in THP-1 cells.
LABs also decreased the protein level of TNF-α.
These results demonstrated that immunobiotics exhibit potent immunoregulatory activity and may be used as effective therapeutic agents to alleviate inflammatory response.
American Psychological Association (APA)
Kanmani, Paulraj& Ansari, AbuZar& Villena, Julio& Kim, Hojun. 2019. Immunobiotics Beneficially Modulate TLR4 Signaling Triggered by Lipopolysaccharide and Reduce Hepatic Steatosis In Vitro. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1176135
Modern Language Association (MLA)
Kanmani, Paulraj…[et al.]. Immunobiotics Beneficially Modulate TLR4 Signaling Triggered by Lipopolysaccharide and Reduce Hepatic Steatosis In Vitro. Journal of Immunology Research No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1176135
American Medical Association (AMA)
Kanmani, Paulraj& Ansari, AbuZar& Villena, Julio& Kim, Hojun. Immunobiotics Beneficially Modulate TLR4 Signaling Triggered by Lipopolysaccharide and Reduce Hepatic Steatosis In Vitro. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1176135
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176135