The Crosstalk between Fat Homeostasis and Liver Regional Immunity in NAFLD
Joint Authors
Liang, Tingming
Ma, Minjuan
Duan, Rui
Zhong, Hong
Guo, Li
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The liver is well known as the center of glucose and lipid metabolism in the human body.
It also functions as an immune organ.
Previous studies have suggested that liver nonparenchymal cells are crucial in the progression of NAFLD.
In recent years, NAFLD’s threat to human health has been becoming a global issue.
And by far, there is no effective treatment for NAFLD.
Liver nonparenchymal cells are stimulated by lipid antigens, adipokines, or other factors, and secreted immune factors can alter the expression of key proteins such as SREBP-1c, ChREBP, and PPARγ to regulate lipid metabolism, thus affecting the pathological process of NAFLD.
Interestingly, some ncRNAs (including miRNAs and lncRNAs) participate in the pathological process of NAFLD by changing body fat homeostasis.
And even some ncRNAs could regulate the activity of HSCs, thereby affecting the progression of inflammation and fibrosis in the course of NAFLD.
In conclusion, immunotherapy could be an effective way to treat NAFLD.
American Psychological Association (APA)
Ma, Minjuan& Duan, Rui& Zhong, Hong& Liang, Tingming& Guo, Li. 2019. The Crosstalk between Fat Homeostasis and Liver Regional Immunity in NAFLD. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1176150
Modern Language Association (MLA)
Ma, Minjuan…[et al.]. The Crosstalk between Fat Homeostasis and Liver Regional Immunity in NAFLD. Journal of Immunology Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1176150
American Medical Association (AMA)
Ma, Minjuan& Duan, Rui& Zhong, Hong& Liang, Tingming& Guo, Li. The Crosstalk between Fat Homeostasis and Liver Regional Immunity in NAFLD. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1176150
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176150