Similar Transition Processes in Synovial Fibroblasts from Rheumatoid Arthritis and Osteoarthritis: A Single-Cell Study
Joint Authors
Zheng, Fang
Ye, Cong
Cai, Shaozhe
Ming, Bingxia
Lin, Shengyan
Hu, Peng
Tang, Jungen
Dong, Lingli
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) and osteoarthritis (OA) are common rheumatic disorders that primarily involve joints.
The inflammation of the synovium can be observed in both of the two diseases.
Synovial fibroblasts (SFs) play an important role in the inflammatory process of the synovium.
The functional states of synovial fibroblasts are heterogeneous, and the detailed transition process of their functional states is still unclear.
By using transcriptomic data of SFs at a single-cell level, we found a similar transition process for SFs in RA and OA.
We also identified the potential regulatory effects of the WNT signaling pathway, the TGF-β signaling pathway, the FcεRI signaling pathway, and the ERBB signaling pathway on modifying the SFs’ functional state.
These findings indicate potentially overlapped pathogenic mechanisms in these two diseases, which may help uncover new therapeutic targets to ameliorate disease progression.
American Psychological Association (APA)
Cai, Shaozhe& Ming, Bingxia& Ye, Cong& Lin, Shengyan& Hu, Peng& Tang, Jungen…[et al.]. 2019. Similar Transition Processes in Synovial Fibroblasts from Rheumatoid Arthritis and Osteoarthritis: A Single-Cell Study. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1176169
Modern Language Association (MLA)
Cai, Shaozhe…[et al.]. Similar Transition Processes in Synovial Fibroblasts from Rheumatoid Arthritis and Osteoarthritis: A Single-Cell Study. Journal of Immunology Research No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1176169
American Medical Association (AMA)
Cai, Shaozhe& Ming, Bingxia& Ye, Cong& Lin, Shengyan& Hu, Peng& Tang, Jungen…[et al.]. Similar Transition Processes in Synovial Fibroblasts from Rheumatoid Arthritis and Osteoarthritis: A Single-Cell Study. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1176169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176169