Clinical Characterization of Patients with Chronic Spontaneous Urticaria according to Anti-TPO IgE Levels
Joint Authors
Sánchez, Andres
Cardona, Ricardo
Sánchez Caraballo, Jorge Mario
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Chronic spontaneous urticaria (CSU) is a heterogeneous disease with some frequent comorbidities like autoimmune diseases, drug reactions, and inducible urticaria.
IgE antibodies against thyroid peroxidase (anti-TPO IgE) could be associated with some of these clinical characteristics.
Objective.
To explore the clinical characteristics of CSU patients, according to the presence of anti-TPO IgE in serum.
Methods.
Anti-TPO IgE levels were measured during the clinical control period (Urticaria Activity Score, 0 point) and exacerbation period (≥3 points) in 100 CSU patients.
Patients with self-reported exacerbation of skin involvement by foods, nonsteroidal anti-inflammatory drugs (NSAIDs), and physical triggers underwent controlled challenge tests.
Results.
We identified 2 groups of patients: (1) patients with anti-TPO IgE during the clinical control period or during an exacerbation, who had a higher frequency of atopy, asthma, and positive challenge test results with NSAIDs and (2) patients without anti-TPO IgE during any period, who had a higher frequency of positive challenge test results for inducible urticaria.
Among the first group (anti-TPO IgE at any point), we identified 3 subgroups: patients with anti-TPO IgE during the clinical control period (n=12); patients with anti-TPO IgE during the clinical control period and significantly increased levels during an urticaria exacerbation (n=18); and patients with anti-TPO IgE only during an exacerbation (n=13).
None of the patients with self-reported food reactions had a positive challenge test result.
Conclusion.
Anti-TPO IgE is a useful biomarker for differentiating between clinical phenotypes of patients with CSU.
Elevation of anti-TPO IgE during exacerbation periods supports an association between this autoantibody and the pathogenesis of urticaria.
American Psychological Association (APA)
Sánchez Caraballo, Jorge Mario& Sánchez, Andres& Cardona, Ricardo. 2019. Clinical Characterization of Patients with Chronic Spontaneous Urticaria according to Anti-TPO IgE Levels. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1176181
Modern Language Association (MLA)
Sánchez Caraballo, Jorge Mario…[et al.]. Clinical Characterization of Patients with Chronic Spontaneous Urticaria according to Anti-TPO IgE Levels. Journal of Immunology Research No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1176181
American Medical Association (AMA)
Sánchez Caraballo, Jorge Mario& Sánchez, Andres& Cardona, Ricardo. Clinical Characterization of Patients with Chronic Spontaneous Urticaria according to Anti-TPO IgE Levels. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1176181
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176181