![](/images/graphics-bg.png)
Further Validation of a Rapid Screening Semiquantitative Thin-Layer Chromatographic Method for Marketed Antimalarial Medicines for Adoption in Malawi
Joint Authors
Osei-Safo, Dorcas
Chikowe, Ibrahim
Harrison, Jerry Joe Ebow Kingsley
Yeboah, Daniel Konadu
Addae-Mensah, Ivan
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A recently developed semiquantitative thin-layer chromatographic (SQ-TLC) assay has been employed in postmarketing surveillance of antimalarial medicines used in Malawi prior to HPLC assay.
Both methods gave analogous results in a significant majority of the samples, with a good correlation (r = 0.9012) for the active pharmaceutical ingredients of the dosage forms assayed.
Artemether-containing medicines had the highest percentage (92.67%) of samples with comparable results for both assays.
The lowest percentage (66.67%) was observed in artesunate-containing medicines.
The SQ-TLC method was validated for specificity, accuracy, precision, linearity, and stability according to the International Conference on Harmonisation guidelines, with the results falling within acceptable limits.
For specificity, retention factor values of the test samples and reference standards were comparable, while accuracy and precision of 91.1 ± 5.7% were obtained for all samples.
The method was linear in the range 1.0–2.0 µg/spot with a correlation coefficient of r = 0.9783.
Stability tests also fell within acceptable limits.
In this study, we present the validation of the SQ-TLC method and propose its adoption as a rapid screening tool for field estimation of the quality of antimalarial and other essential medicines in Malawi and other parts of the developing world prior to a more accurate HPLC assay.
American Psychological Association (APA)
Osei-Safo, Dorcas& Chikowe, Ibrahim& Harrison, Jerry Joe Ebow Kingsley& Yeboah, Daniel Konadu& Addae-Mensah, Ivan. 2018. Further Validation of a Rapid Screening Semiquantitative Thin-Layer Chromatographic Method for Marketed Antimalarial Medicines for Adoption in Malawi. Journal of Analytical Methods in Chemistry،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1176219
Modern Language Association (MLA)
Osei-Safo, Dorcas…[et al.]. Further Validation of a Rapid Screening Semiquantitative Thin-Layer Chromatographic Method for Marketed Antimalarial Medicines for Adoption in Malawi. Journal of Analytical Methods in Chemistry No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1176219
American Medical Association (AMA)
Osei-Safo, Dorcas& Chikowe, Ibrahim& Harrison, Jerry Joe Ebow Kingsley& Yeboah, Daniel Konadu& Addae-Mensah, Ivan. Further Validation of a Rapid Screening Semiquantitative Thin-Layer Chromatographic Method for Marketed Antimalarial Medicines for Adoption in Malawi. Journal of Analytical Methods in Chemistry. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1176219
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176219