Development and Validation of an Extractive Spectrophotometric Method for Miconazole Nitrate Assay in Pharmaceutical Formulations
Joint Authors
Kahsay, Getu
Kidanemariam, Hailekiros Gebretsadik
Eticha, Tadele
Hailu, Teklebrhan
Gebretsadikan, Tesfamichael
Asefa, Fitsum
Thangabalan, Boovizhikannan
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A simple extractive spectrophotometric technique has been developed and validated for the determination of miconazole nitrate in pure and pharmaceutical formulations.
The method is based on the formation of a chloroform-soluble ion-pair complex between the drug and bromocresol green (BCG) dye in an acidic medium.
The complex showed absorption maxima at 422 nm, and the system obeys Beer’s law in the concentration range of 1–30 µg/mL with molar absorptivity of 2.285 × 104 L/mol/cm.
The composition of the complex was studied by Job’s method of continuous variation, and the results revealed that the mole ratio of drug : BCG is 1 : 1.
Full factorial design was used to optimize the effect of variable factors, and the method was validated based on the ICH guidelines.
The method was applied for the determination of miconazole nitrate in real samples.
American Psychological Association (APA)
Eticha, Tadele& Kahsay, Getu& Hailu, Teklebrhan& Gebretsadikan, Tesfamichael& Asefa, Fitsum& Kidanemariam, Hailekiros Gebretsadik…[et al.]. 2018. Development and Validation of an Extractive Spectrophotometric Method for Miconazole Nitrate Assay in Pharmaceutical Formulations. Journal of Analytical Methods in Chemistry،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1176249
Modern Language Association (MLA)
Eticha, Tadele…[et al.]. Development and Validation of an Extractive Spectrophotometric Method for Miconazole Nitrate Assay in Pharmaceutical Formulations. Journal of Analytical Methods in Chemistry No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1176249
American Medical Association (AMA)
Eticha, Tadele& Kahsay, Getu& Hailu, Teklebrhan& Gebretsadikan, Tesfamichael& Asefa, Fitsum& Kidanemariam, Hailekiros Gebretsadik…[et al.]. Development and Validation of an Extractive Spectrophotometric Method for Miconazole Nitrate Assay in Pharmaceutical Formulations. Journal of Analytical Methods in Chemistry. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1176249
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176249