Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization
Joint Authors
Zhang, Dayong
Pan, Jianping
Pan, Zheng-yang
Yu, Xiong-kai
Chen, Yi-fan
Gao, Chen-hao
Yang, Yu-tian
Jiang, Xue-fan
Li, Na
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Immunosenescence comprises a set of dynamic changes occurring in innate and adaptive immune systems, and macrophage aging plays an important role in innate and adaptive immunosenescence.
However, function and polarization changes in aging macrophages have not been fully evaluated, and no effective method for delaying macrophage senescence is currently available.
The results of this study reveal that D-galactose (D-gal) can promote J774A.1 macrophage senescence and induce macrophage M1 polarization differentiation.
Bifidobacterium lactis BB-12 can significantly inhibit J774A.1 macrophage senescence induced by D-gal.
IL-6 and IL-12 levels in the BB-12 groups remarkably decreased compared with that in the D-gal group, and the M2 marker, IL-10, and Arg-1 mRNA levels increased in the BB-12 group.
BB-12 inhibited the expression of p-signal transducer and activator of transcription 1 (STAT1) and promoted p-STAT6 expression.
In summary, the present study indicates that BB-12 can attenuate the J774A.1 macrophage senescence and induce M2 macrophage polarization, thereby indicating the potential of BB-12 to slow down immunosenescence and inflamm-aging.
American Psychological Association (APA)
Zhang, Dayong& Pan, Zheng-yang& Yu, Xiong-kai& Chen, Yi-fan& Gao, Chen-hao& Yang, Yu-tian…[et al.]. 2019. Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1176253
Modern Language Association (MLA)
Zhang, Dayong…[et al.]. Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization. Journal of Immunology Research No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1176253
American Medical Association (AMA)
Zhang, Dayong& Pan, Zheng-yang& Yu, Xiong-kai& Chen, Yi-fan& Gao, Chen-hao& Yang, Yu-tian…[et al.]. Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1176253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176253