Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity
Joint Authors
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The mammalian intestine harbors a remarkable number of microbes and their components and metabolites, which are fundamental for the instigation and development of the host immune system.
The intestinal innate and adaptive immunity coordinate and interact with the symbionts contributing to the intestinal homeostasis through establishment of a mutually beneficial relationship by tolerating to symbiotic microbiota and retaining the ability to exert proinflammatory response towards invasive pathogens.
Imbalance between the intestinal immune system and commensal organisms disrupts the intestinal microbiological homeostasis, leading to microbiota dysbiosis, compromised integrity of the intestinal barrier, and proinflammatory immune responses towards symbionts.
This, in turn, exacerbates the degree of the imbalance.
Intestinal adaptive immunity plays a critical role in maintaining immune tolerance towards symbionts and the integrity of intestinal barrier, while the innate immune system regulates the adaptive immune responses to intestinal commensal bacteria.
In this review, we will summarize recent findings on the effects and mechanisms of gut microbiota on intestinal adaptive immunity and the plasticity of several immune cells under diverse microenvironmental settings.
American Psychological Association (APA)
Wang, Li& Zhu, Limeng& Qin, Song. 2019. Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1176261
Modern Language Association (MLA)
Wang, Li…[et al.]. Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity. Journal of Immunology Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1176261
American Medical Association (AMA)
Wang, Li& Zhu, Limeng& Qin, Song. Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1176261
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176261