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Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease Onset
Joint Authors
Nguyen, Cuong Q.
Peck, Ammon B.
Witas, Richard
Ambrus, Julian L.
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Sjogren’s syndrome (SS) is a chronic, progressive autoimmune disease featuring both organ-specific and systemic manifestations, the most frequent being dry mouth and dry eyes resulting from lymphocytic infiltration into the salivary and lacrimal glands.
Like the related autoimmune disease systemic lupus erythematosus (SLE), SS patients and mouse models display accumulation of apoptotic cells and a Type I interferon (IFN) signature.
Receptor tyrosine kinases (RTKs) of the Tyro3, Axl, and Mer (TAM) family are present on the surface of macrophages and dendritic cells and participate in phagocytosis of apoptotic cells (efferocytosis) and inhibition of Type I IFN signaling.
This review examines the relationship between TAM receptor dysfunction and SS and explores the potential contributions of TAM defects on macrophages to SS development.
American Psychological Association (APA)
Witas, Richard& Peck, Ammon B.& Ambrus, Julian L.& Nguyen, Cuong Q.. 2019. Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease Onset. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1176282
Modern Language Association (MLA)
Peck, Ammon B.…[et al.]. Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease Onset. Journal of Immunology Research No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1176282
American Medical Association (AMA)
Witas, Richard& Peck, Ammon B.& Ambrus, Julian L.& Nguyen, Cuong Q.. Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease Onset. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1176282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176282