NotchCXCR4 Partnership in Acute Lymphoblastic Leukemia Progression
Joint Authors
Felli, Maria Pia
Ferretti, Elisabetta
Vacca, Alessandra
Tsaouli, Georgia
Bellavia, Diana
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Acute lymphoblastic leukemia (ALL) is the most common cancer among children.
Recent advances in chemotherapy have made ALL a curable hematological malignancy.
In children, there is 25% chance of disease relapse, typically in the central nervous system.
While in adults, there is a higher chance of relapse.
ALL may affect B-cell or T-cell lineages.
Different genetic alterations characterize the two ALL forms.
Deregulated Notch, either Notch1 or Notch3, and CXCR4 receptor signaling are involved in ALL disease development and progression.
By analyzing their relevant roles in the pathogenesis of the two ALL forms, new molecular mechanisms able to modulate cancer cell invasion may be visualized.
Notably, the partnership between Notch and CXCR4 may have considerable implications in understanding the complexity of T- and B-ALL.
These two receptor pathways intersect other critical signals in the proliferative, differentiation, and metabolic programs of lymphocyte transformation.
Also, the identification of the crosstalks in leukemia-stroma interaction within the tumor microenvironment may unveil new targetable mechanisms in disease relapse.
Further studies are required to identify new challenges and opportunities to develop more selective and safer therapeutic strategies in ALL progression, possibly contributing to improve conventional hematological cancer therapy.
American Psychological Association (APA)
Tsaouli, Georgia& Ferretti, Elisabetta& Bellavia, Diana& Vacca, Alessandra& Felli, Maria Pia. 2019. NotchCXCR4 Partnership in Acute Lymphoblastic Leukemia Progression. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1176354
Modern Language Association (MLA)
Tsaouli, Georgia…[et al.]. NotchCXCR4 Partnership in Acute Lymphoblastic Leukemia Progression. Journal of Immunology Research No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1176354
American Medical Association (AMA)
Tsaouli, Georgia& Ferretti, Elisabetta& Bellavia, Diana& Vacca, Alessandra& Felli, Maria Pia. NotchCXCR4 Partnership in Acute Lymphoblastic Leukemia Progression. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1176354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176354