Increased Serum Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) Levels in FSGS: A Meta-Analysis
Joint Authors
Eisenhut, Michael
Kronbichler, Andreas
Shin, Jae Il
Lee, Jiwon M.
Lee, Keum Hwa
Yang, Jae Won
Kim, Gaeun
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Introduction.
The soluble urokinase-type plasminogen activator receptor (suPAR) has been found to be elevated in primary focal segmental glomerulosclerosis (pFSGS).
However, its usefulness as a biomarker for FSGS remains controversial.
We conducted a meta-analysis aiming at investigating the significance of suPAR in diagnosing pFSGS.
Methods.
Electronic databases (PubMed and EMBASE) were searched to identify studies comparing suPAR levels in FSGS patients and controls, from the earliest available date to May 1, 2018.
A random-effects model with standardized mean difference (SMD) was used for meta-analyses.
Risk of bias was assessed using the Newcastle-Ottawa quality assessment scale.
Results.
A total of 187 articles were screened, and the final analysis included 13 articles.
In comparison to healthy controls, serum suPAR levels were significantly increased in pFSGS patients (SMD, 1.07, 95% confidence interval (CI) 0.65 to 1.48; participants=814; studies=9, I2=85%).
Higher suPAR levels were also found in patients with pFSGS compared to those with minimal change disease (SMD 0.53, 95% CI 0.22 to 0.84).
Of note, such a difference was not found in pediatric groups (SMD 0.42, 95% CI -0.13 to 0.96) while it was more evidently noted in adult patients (SMD 1.32, 95% CI 0.90 to 1.74).
Serum suPAR levels did not differ between pFSGS patients in remission compared to those in active proteinuric state (SMD 0.29, 95% CI -0.30 to 0.88).
Comparison with membranous nephropathy and IgA nephropathy showed no significant difference.
Conclusions.
Our meta-analysis demonstrated that, in comparison to both healthy controls and controls with minimal change disease, suPAR levels were significantly higher in adult patients with pFSGS.
suPAR levels did not differ between pFSGS patients during the initial period of diagnosis and those in remission.
American Psychological Association (APA)
Lee, Jiwon M.& Yang, Jae Won& Kronbichler, Andreas& Eisenhut, Michael& Kim, Gaeun& Lee, Keum Hwa…[et al.]. 2019. Increased Serum Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) Levels in FSGS: A Meta-Analysis. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1176357
Modern Language Association (MLA)
Lee, Jiwon M.…[et al.]. Increased Serum Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) Levels in FSGS: A Meta-Analysis. Journal of Immunology Research No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1176357
American Medical Association (AMA)
Lee, Jiwon M.& Yang, Jae Won& Kronbichler, Andreas& Eisenhut, Michael& Kim, Gaeun& Lee, Keum Hwa…[et al.]. Increased Serum Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) Levels in FSGS: A Meta-Analysis. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1176357
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176357