Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases
Joint Authors
Yin, Geng
Xie, Qi-bing
Chen, Yuehong
Sun, Jianhong
Liu, Huan
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chimeric antigen receptor T (CAR-T) cells are T cells engineered to express specific synthetic antigen receptors that can recognize antigens expressed by tumor cells, which after the binding of these antigens to the receptors are eliminated, and have been adopted to treat several kinds of malignancies.
Autoimmune diseases (AIDs), a class of chronic disease conditions, can be broadly separated into autoantibody-mediated and T cell-mediated diseases.
Treatments for AIDs are focused on restoring immune tolerance.
However, current treatments have little effect on immune tolerance inverse; even the molecular target biologics like anti-TNFα inhibitors can only mildly restore immune balance.
By using the idea of CAR-T cell treatment in tumors, CAR-T cell-derived immunotherapies, chimeric autoantibody receptor T (CAAR-T) cells, and CAR regulatory T (CAR-T) cells bring new hope of treatment choice for AIDs.
American Psychological Association (APA)
Chen, Yuehong& Sun, Jianhong& Liu, Huan& Yin, Geng& Xie, Qi-bing. 2019. Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1176360
Modern Language Association (MLA)
Chen, Yuehong…[et al.]. Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases. Journal of Immunology Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1176360
American Medical Association (AMA)
Chen, Yuehong& Sun, Jianhong& Liu, Huan& Yin, Geng& Xie, Qi-bing. Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1176360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176360