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Immunomodulation of CXCL10 Secretion by Hepatitis C Virus: Could CXCL10 Be a Prognostic Marker of Chronic Hepatitis C?
Joint Authors
Antonelli, Alessandro
Fallahi, Poupak
Elia, Giusy
Ragusa, Francesca
Paparo, Sabrina Rosaria
Patrizio, Armando
Mazzi, Valeria
Giuggioli, Dilia
Ferri, Clodoveo
Colaci, Michele
Ferrari, Silvia Martina
Ruffilli, Ilaria
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Chemokine (C-X-C motif) ligand (CXCL)10 and other CXCR3 chemokines are involved in the pathogenesis of acute and “chronic hepatitis C virus (HCV) infection” (CHC).
Here, we review the scientific literature about HCV and CXCL10.
The combination of circulating CXCL10 and single nucleotide polymorphisms (SNPs) in IL-28B can identify patients with acute HCV infection most likely to undergo spontaneous HCV clearance and those in need of early antiviral therapy.
In CHC, the HCV and intrahepatic interferon- (IFN-) γ drive a raised CXCL10 expression by sinusoidal endothelium and hepatocytes, thereby inducing the recruitment of CXCR3-expressing T cells into the liver; thus, CXCL10 plays an important role in the development of necroinflammation and fibrosis.
Increased CXCL10 was significantly associated with the presence of active vasculitis in HCV-associated cryoglobulinemia, or with autoimmune thyroiditis in CHC.
Pretreatment CXCL10 levels are predictive of early virological response and sustained virological response (SVR) to IFN-α and ribavirin and may be useful in the evaluation of candidates for therapy.
The occurrence of SNPs adjacent to IL-28B (rs12979860, rs12980275, and rs8099917), and CXCL10 below 150 pg/mL, independently predicted the first phase viral decline and rapid virological response, which in turn independently predicted SVR.
Directly acting antiviral agents-mediated clearance of HCV is associated with the loss of intrahepatic immune activation by IFN-α, associated by decreased levels of CXCL10.
In conclusion, CXCL10 is an important marker of HCV clearance and successful therapy in CHC patients.
Whether CXCL10 is a novel therapeutic target in CHC will be evaluated.
American Psychological Association (APA)
Ferrari, Silvia Martina& Fallahi, Poupak& Ruffilli, Ilaria& Elia, Giusy& Ragusa, Francesca& Paparo, Sabrina Rosaria…[et al.]. 2019. Immunomodulation of CXCL10 Secretion by Hepatitis C Virus: Could CXCL10 Be a Prognostic Marker of Chronic Hepatitis C?. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1176381
Modern Language Association (MLA)
Ferrari, Silvia Martina…[et al.]. Immunomodulation of CXCL10 Secretion by Hepatitis C Virus: Could CXCL10 Be a Prognostic Marker of Chronic Hepatitis C?. Journal of Immunology Research No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1176381
American Medical Association (AMA)
Ferrari, Silvia Martina& Fallahi, Poupak& Ruffilli, Ilaria& Elia, Giusy& Ragusa, Francesca& Paparo, Sabrina Rosaria…[et al.]. Immunomodulation of CXCL10 Secretion by Hepatitis C Virus: Could CXCL10 Be a Prognostic Marker of Chronic Hepatitis C?. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1176381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176381