Preoperative Risk Assessment of Lymph Node Metastasis in cT1 Lung Cancer: A Retrospective Study from Eastern China
Joint Authors
Zhang, Chengyan
Pang, Guanchao
Ma, Chengxi
Wu, Jingni
Wang, Pingli
Wang, Kai
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Lymph node status of clinical T1 (diameter≤3 cm) lung cancer largely affects the treatment strategies in the clinic.
In order to assess lymph node status before operation, we aim to develop a noninvasive predictive model using preoperative clinical information.
Methods.
We retrospectively reviewed 924 patients (development group) and 380 patients (validation group) of clinical T1 lung cancer.
Univariate analysis followed by polytomous logistic regression was performed to estimate different risk factors of lymph node metastasis between N1 and N2 diseases.
A predictive model of N2 metastasis was established with dichotomous logistic regression, externally validated and compared with previous models.
Results.
Consolidation size and clinical N stage based on CT were two common independent risk factors for both N1 and N2 metastases, with different odds ratios.
For N2 metastasis, we identified five independent predictors by dichotomous logistic regression: peripheral location, larger consolidation size, lymph node enlargement on CT, no smoking history, and higher levels of serum CEA.
The model showed good calibration and discrimination ability in the development data, with the reasonable Hosmer-Lemeshow test (p=0.839) and the area under the ROC being 0.931 (95% CI: 0.906-0.955).
When externally validated, the model showed a great negative predictive value of 97.6% and the AUC of our model was better than other models.
Conclusion.
In this study, we analyzed risk factors for both N1 and N2 metastases and built a predictive model to evaluate possibilities of N2 metastasis of clinical T1 lung cancers before the surgery.
Our model will help to select patients with low probability of N2 metastasis and assist in clinical decision to further management.
American Psychological Association (APA)
Zhang, Chengyan& Pang, Guanchao& Ma, Chengxi& Wu, Jingni& Wang, Pingli& Wang, Kai. 2019. Preoperative Risk Assessment of Lymph Node Metastasis in cT1 Lung Cancer: A Retrospective Study from Eastern China. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1176474
Modern Language Association (MLA)
Zhang, Chengyan…[et al.]. Preoperative Risk Assessment of Lymph Node Metastasis in cT1 Lung Cancer: A Retrospective Study from Eastern China. Journal of Immunology Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1176474
American Medical Association (AMA)
Zhang, Chengyan& Pang, Guanchao& Ma, Chengxi& Wu, Jingni& Wang, Pingli& Wang, Kai. Preoperative Risk Assessment of Lymph Node Metastasis in cT1 Lung Cancer: A Retrospective Study from Eastern China. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1176474
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176474