Development and Validation of Gas Chromatography-Triple Quadrupole Mass Spectrometric Method for Quantitative Determination of Regulated Plasticizers in Medical Infusion Sets
Joint Authors
Jeon, So Hyeon
Shin, Jeoung Hwa
Ahn, Yun Gyong
Kim, Yong Pyo
Kho, Younglim
Ji, Won Hyun
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A method for the quantitative determination of dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), bis(2-ethylhexyl) adipate (DEHA), bis(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DNOP), dioctyl terephthalate (DOTP), diisononyl phthalate (DINP), and diisodecyl phthalate (DIDP) in medical infusion sets was developed and validated using gas chromatography coupled with triple quadrupole mass spectrometry (GC-MS/MS) in the multiple reaction monitoring (MRM) mode.
Solvent extraction with polymer dissolution for sample preparation was employed prior to GC-MS/MS analysis.
Average recoveries of the eight target analytes are typically in the range of 91.8–122% with the relative standard deviations of 1.8–17.8%.
The limits of quantification (LOQs) of the analytical method were in the ranges of 54.1 to 76.3 ng/g.
Analysis using GC-MS/MS provided reliable performance, as well as higher sensitivity and selectivity than GC-MS analysis, especially for the presence of minority plasticizers at different concentrations.
American Psychological Association (APA)
Jeon, So Hyeon& Kim, Yong Pyo& Kho, Younglim& Shin, Jeoung Hwa& Ji, Won Hyun& Ahn, Yun Gyong. 2018. Development and Validation of Gas Chromatography-Triple Quadrupole Mass Spectrometric Method for Quantitative Determination of Regulated Plasticizers in Medical Infusion Sets. Journal of Analytical Methods in Chemistry،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1176670
Modern Language Association (MLA)
Jeon, So Hyeon…[et al.]. Development and Validation of Gas Chromatography-Triple Quadrupole Mass Spectrometric Method for Quantitative Determination of Regulated Plasticizers in Medical Infusion Sets. Journal of Analytical Methods in Chemistry No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1176670
American Medical Association (AMA)
Jeon, So Hyeon& Kim, Yong Pyo& Kho, Younglim& Shin, Jeoung Hwa& Ji, Won Hyun& Ahn, Yun Gyong. Development and Validation of Gas Chromatography-Triple Quadrupole Mass Spectrometric Method for Quantitative Determination of Regulated Plasticizers in Medical Infusion Sets. Journal of Analytical Methods in Chemistry. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1176670
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176670