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Chemometric-Assisted Spectrophotometric Method for the Simultaneous Determination of Ciprofloxacin and Doxycycline Hyclate in Pharmaceutical Formulations
Joint Authors
Kahsay, Getu
Kidanemariam, Hailekiros Gebretsadik
Eticha, Tadele
Hailu, Teklebrhan
Gebretsadikan, Tesfamichael
Asefa, Fitsum
Thangabalan, Boovizhikannan
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Two chemometrics methods—principal component regression and partial least squares—were developed for simultaneous spectrophotometric estimation of ciprofloxacin and doxycycline hyclate in pharmaceutical dosage forms without any pretreatment.
The UV spectra of both drugs were recorded at concentrations within their linear ranges between 200 and 400 nm with the intervals λ = 2 nm at 100 wavelengths in distilled water.
Beer’s law was obeyed for both drugs in the concentration ranges of 1–10 μg/mL for ciprofloxacin and 5–25 μg/mL for doxycycline hyclate.
Two sets of standard mixtures, 25 as a calibration set and 9 as a validation set, were prepared.
The calibration models were evaluated by cross-validation and external validation over synthetic mixtures.
The optimized models were successfully applied for chemometric analysis of ciprofloxacin and doxycycline hyclate in synthetic and pharmaceutical mixtures with satisfactory accuracy (recovery values from 97.50% to 101.87%) and precision (RSD < 2%).
American Psychological Association (APA)
Eticha, Tadele& Kahsay, Getu& Asefa, Fitsum& Hailu, Teklebrhan& Kidanemariam, Hailekiros Gebretsadik& Gebretsadikan, Tesfamichael…[et al.]. 2018. Chemometric-Assisted Spectrophotometric Method for the Simultaneous Determination of Ciprofloxacin and Doxycycline Hyclate in Pharmaceutical Formulations. Journal of Analytical Methods in Chemistry،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1176681
Modern Language Association (MLA)
Eticha, Tadele…[et al.]. Chemometric-Assisted Spectrophotometric Method for the Simultaneous Determination of Ciprofloxacin and Doxycycline Hyclate in Pharmaceutical Formulations. Journal of Analytical Methods in Chemistry No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1176681
American Medical Association (AMA)
Eticha, Tadele& Kahsay, Getu& Asefa, Fitsum& Hailu, Teklebrhan& Kidanemariam, Hailekiros Gebretsadik& Gebretsadikan, Tesfamichael…[et al.]. Chemometric-Assisted Spectrophotometric Method for the Simultaneous Determination of Ciprofloxacin and Doxycycline Hyclate in Pharmaceutical Formulations. Journal of Analytical Methods in Chemistry. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1176681
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176681