Systematic Evaluation of Chromatographic Parameters for Isoquinoline Alkaloids on XB-C18 Core-Shell Column Using Different Mobile Phase Compositions
Joint Authors
Sowa, Ireneusz
Zielińska, Sylwia
Sawicki, Jan
Bogucka-Kocka, Anna
Staniak, Michał
Bartusiak-Szcześniak, Ewa
Podolska-Fajks, Maja
Kocjan, Ryszard
Wójciak-Kosior, Magdalena
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Chelidonium majus L.
is a rich source of isoquinoline alkaloids with confirmed anti-inflammatory, choleretic, spasmolytic, antitumor, and antimicrobial activities.
However, their chromatographic analysis is difficult because they may exist both in charged and uncharged forms and may result in the irregular peak shape and the decrease in chromatographic system efficacy.
In the present work, the separation of main C.
majus alkaloids was optimized using a new-generation XB-C18 endcapped core-shell column dedicated for analysis of alkaline compounds.
The influence of organic modifier concentration, addition of salts, and pH of eluents on chromatographic parameters such as retention, resolution, chromatographic plate numbers, and peak asymmetry was investigated.
The results were applied to elaborate the optimal chromatographic system for simultaneous quantification of seven alkaloids from the root, herb, and fruit of C.
majus.
American Psychological Association (APA)
Sowa, Ireneusz& Zielińska, Sylwia& Sawicki, Jan& Bogucka-Kocka, Anna& Staniak, Michał& Bartusiak-Szcześniak, Ewa…[et al.]. 2018. Systematic Evaluation of Chromatographic Parameters for Isoquinoline Alkaloids on XB-C18 Core-Shell Column Using Different Mobile Phase Compositions. Journal of Analytical Methods in Chemistry،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1176686
Modern Language Association (MLA)
Sowa, Ireneusz…[et al.]. Systematic Evaluation of Chromatographic Parameters for Isoquinoline Alkaloids on XB-C18 Core-Shell Column Using Different Mobile Phase Compositions. Journal of Analytical Methods in Chemistry No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1176686
American Medical Association (AMA)
Sowa, Ireneusz& Zielińska, Sylwia& Sawicki, Jan& Bogucka-Kocka, Anna& Staniak, Michał& Bartusiak-Szcześniak, Ewa…[et al.]. Systematic Evaluation of Chromatographic Parameters for Isoquinoline Alkaloids on XB-C18 Core-Shell Column Using Different Mobile Phase Compositions. Journal of Analytical Methods in Chemistry. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1176686
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176686