Association of metabolic syndrome with development of pre-eclampsia among pregnant women

Abstract EN

Background: Preeclampsia is a complicated disorder in pregnancy which occurs after 20 weeks of gestation.

It affects 3-5% of all pregnancies in the world.

It has been reported that the prevalence of preeclampsia has been altered between 1.8% and 16.7% in developing countries Women with preeclampsia seem to be at elevated risk for cardiovascular disease.

Objective: This study was doneto determine the relation between metabolic syndrome and occurance of pre-eclampsia and to evaluate the use of metabolic score in determining the devolpment and severity of pre-eclampsia.

Methods: This is a case-control study includes women attending to obstetric emergency unit in labour.

The period of study was about 24 month from January 2017 to December 2018.

The cases were divided into two groups: The first group consists of 300 cases with pre-eclampsia which characterized by: Mild pre-eclampsia as blood pressure higher than 140/85 and protein 1+ or greater by drip stik, moderate pre-eclsampsia blood pressure is more than 140/85 and less than 160/100 and protein 1+ or greater by drip stik.

Severe pre-eclampsia (imminant-eclampsia) or blood pressure is higher than 160/100 and protein greater than 3+ by drip stik.

The second group consists of 300 control patients with normal pregnancy.

Results: Preeclampsia was a dependent risk factors for metabolic syndrome (adjusted odds ratio = 6.888, 95% CI = 4.656 to 10.189, P-value <0.0001).

While age category 40-49 years was associated with significantly lower risk for metabolic syndrome as referenced to age category 18-29 years adjusted odds ratio = 0.337, 95% CI = 0.168 to 0.677, P-value = 0.002).

Conclusion: There is a significant relation between the incidence of PE and presence of metabolic syndrome and the more number of items of metabolic syndrome the higher the risk of occurrence of PE.