Development of a Method for Rapid Determination of Morpholine in Juices and Drugs by Gas Chromatography-Mass Spectrometry
Joint Authors
Zhang, Pingping
Cao, Mengsi
Feng, Yanru
Zhang, Huayin
Zhu, Huaijiao
Lian, Kaoqi
Kang, Weijun
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A reliable derivatization method has been developed to detect and quantify morpholine in apple juices and ibuprofen with gas chromatography-mass spectrometry.
Morpholine can react with sodium nitrite under acidic condition to produce stable and volatile N-nitrosomorpholine derivative.
In this experiment, various factors affecting the derivatization and extraction process were optimized, including volume and concentration of hydrochloric acid, quantity of sodium nitrite, derivatization temperature, derivatization time, extraction reagents, and extraction time.
The derivative was extracted with dichloromethane and determined by gas chromatography-mass spectrometry.
The linearity range of morpholine was 10–500 μg·L−1 with good correlation, and limits of detection (LOD) and limits of quantification (LOQ) were 7.3 μg·L−1 and 24.4 μg·L−1, respectively.
Low, medium, and high concentrations of morpholine were added in apple juices and ibuprofen samples to evaluate standard recovery rate and relative standard deviation.
The spiked recovery rate ranged from 94.3% to 109.0%, and the intraday repeatability and interday reproducibility were 2.0%–4.4% and 3.3%–7.0%, respectively.
The developed method has good accuracy and precision.
This quantitative method for morpholine is simple, sensitive, rapid, and low cost and can successfully be applied to analyze the residual morpholine in apple juices and drug samples.
American Psychological Association (APA)
Cao, Mengsi& Zhang, Pingping& Feng, Yanru& Zhang, Huayin& Zhu, Huaijiao& Lian, Kaoqi…[et al.]. 2018. Development of a Method for Rapid Determination of Morpholine in Juices and Drugs by Gas Chromatography-Mass Spectrometry. Journal of Analytical Methods in Chemistry،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1180704
Modern Language Association (MLA)
Cao, Mengsi…[et al.]. Development of a Method for Rapid Determination of Morpholine in Juices and Drugs by Gas Chromatography-Mass Spectrometry. Journal of Analytical Methods in Chemistry No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1180704
American Medical Association (AMA)
Cao, Mengsi& Zhang, Pingping& Feng, Yanru& Zhang, Huayin& Zhu, Huaijiao& Lian, Kaoqi…[et al.]. Development of a Method for Rapid Determination of Morpholine in Juices and Drugs by Gas Chromatography-Mass Spectrometry. Journal of Analytical Methods in Chemistry. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1180704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1180704