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Cross-Reaction, Enhancement, and Neutralization Activity of Dengue Virus Antibodies against Zika Virus: A Study in the Mexican Population
Joint Authors
Cedillo-Barrón, Leticia
Vivanco-Cid, H.
Muñoz-Medina, José Esteban
Santos-Argumedo, Leopoldo
Mellado-Sánchez, Gabriela
Montecillo-Aguado, Mayra R.
Montes-Gómez, Alfredo E.
García-Cordero, Julio
Corzo-Gómez, Josselin
Gutiérrez-Castañeda, Benito
González-Bonilla, Cesar
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-02
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Zika virus (ZIKV), an emerging mosquito-borne flavivirus, has quickly spread in many regions around the world where dengue virus (DENV) is endemic.
This represents a major health concern, given the high homology between these two viruses, which can result in cross-reactivity.
The aim of this study was to determine the cross-reacting antibody response of the IgM and IgG classes against the recombinant envelope protein of ZIKV (rE-ZIKV) in sera from patients with acute-phase infection of different clinical forms of dengue, i.e., dengue fever (DF) and dengue hemorrhagic fever (DHF) (before the arrival of ZIKV in Mexico 2010), as well as acute-phase sera of ZIKV patients, together with the implications in neutralization and antibody-dependent enhancement.
Differences in IgM responses were observed in a number of DF and DHF patients whose sera cross-reacted with the rE-ZIK antigen, with 42% recognition between acute-phase DHF and ZIKV but 27% recognition between DF and ZIKV.
Regarding IgG antibodies, 71.5% from the DF group showed cross-reactivity to rE-ZIKV in contrast with 50% and only 25% of DHF and ZIKV serum samples, respectively, which specifically recognized the homologous antigen.
The DHF group showed more enhancement of ZIKV infection of FCRγ-expressing cells compared to the DF group.
Furthermore, the DHF group also showed a higher cross-neutralizing ability than that of DF.
This is the first report where DF and DHF serum samples were evaluated for cross-reactivity against Zika protein and ZIKV.
Furthermore, DENV serum samples cross-protect against ZIKV through neutralizing antibodies but at the same time mediate antibody-dependent enhancement in the sequential ZIKV infection.
American Psychological Association (APA)
Montecillo-Aguado, Mayra R.& Montes-Gómez, Alfredo E.& García-Cordero, Julio& Corzo-Gómez, Josselin& Vivanco-Cid, H.& Mellado-Sánchez, Gabriela…[et al.]. 2019. Cross-Reaction, Enhancement, and Neutralization Activity of Dengue Virus Antibodies against Zika Virus: A Study in the Mexican Population. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1180726
Modern Language Association (MLA)
Montecillo-Aguado, Mayra R.…[et al.]. Cross-Reaction, Enhancement, and Neutralization Activity of Dengue Virus Antibodies against Zika Virus: A Study in the Mexican Population. Journal of Immunology Research No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1180726
American Medical Association (AMA)
Montecillo-Aguado, Mayra R.& Montes-Gómez, Alfredo E.& García-Cordero, Julio& Corzo-Gómez, Josselin& Vivanco-Cid, H.& Mellado-Sánchez, Gabriela…[et al.]. Cross-Reaction, Enhancement, and Neutralization Activity of Dengue Virus Antibodies against Zika Virus: A Study in the Mexican Population. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1180726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1180726