Curcumin Provides Hepatoprotection against Amoebic Liver Abscess Induced by Entamoeba histolytica in Hamster: Involvement of Nrf2HO-1 and NF-κBIL-1β Signaling Pathways
Joint Authors
Muñoz-Ortega, Martin
Ventura-Juárez, Javier
Martínez-Hernández, Sandra Luz
Aldaba-Muruato, Liseth Rubí
Macías-Pérez, José Roberto
Pulido-Ortega, Julieta
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Amoebic liver abscess (ALA) is the most common extraintestinal amoebiasis caused by Entamoeba histolytica (E.
histolytica).
However, despite current knowledge and scientific advances about this infection, there are no effective treatments to prevent it.
Herein, the antiamoebic capacity of curcumin in a hamster model was evaluated.
Curcumin (150 mg/kg, p.o., daily during 10 days before infection) considerably prevents liver damage induced at 12 and 48 h post-intrahepatic inoculation of trophozoites and decreases ALT, ALP, and γ-GTP activities, and macroscopic and microscopic observations were consistent with these results.
On the other hand, after one week of intraportal inoculation, liver damage was prevented by curcumin (150 mg/kg, p.o., daily, 20 days before amoebic inoculation and during the week of infection); liver/body weight ratios and tissue and histological stains showed normal appearance; in addition, the increases in ALT, ALP, and γ-GTP activities were prevented; the depletion of glycogen content induced by the amoebic damage was partially but significantly prevented, while NF-κB activity was inhibited and the expression of IL-1β was reduced; Nrf2 production showed a tendency to increase it, and HO-1 protein was overexpressed.
These results suggest for the first time that curcumin can be a compound with antiamoebic effect in the liver, suggesting that its daily use could help greatly decrease the incidence of this type of infection.
American Psychological Association (APA)
Macías-Pérez, José Roberto& Aldaba-Muruato, Liseth Rubí& Martínez-Hernández, Sandra Luz& Muñoz-Ortega, Martin& Pulido-Ortega, Julieta& Ventura-Juárez, Javier. 2019. Curcumin Provides Hepatoprotection against Amoebic Liver Abscess Induced by Entamoeba histolytica in Hamster: Involvement of Nrf2HO-1 and NF-κBIL-1β Signaling Pathways. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1180768
Modern Language Association (MLA)
Macías-Pérez, José Roberto…[et al.]. Curcumin Provides Hepatoprotection against Amoebic Liver Abscess Induced by Entamoeba histolytica in Hamster: Involvement of Nrf2HO-1 and NF-κBIL-1β Signaling Pathways. Journal of Immunology Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1180768
American Medical Association (AMA)
Macías-Pérez, José Roberto& Aldaba-Muruato, Liseth Rubí& Martínez-Hernández, Sandra Luz& Muñoz-Ortega, Martin& Pulido-Ortega, Julieta& Ventura-Juárez, Javier. Curcumin Provides Hepatoprotection against Amoebic Liver Abscess Induced by Entamoeba histolytica in Hamster: Involvement of Nrf2HO-1 and NF-κBIL-1β Signaling Pathways. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1180768
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1180768