Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice
Joint Authors
Guo, Jinbo
Yin, Fengrong
Huo, Xiaoxia
Luo, Yuxin
Niu, Guochao
Song, Mei
Chen, Shuang
Zhang, Xiaolan
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-14
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Macrophages are the master regulator of the dynamic fibrogenesis–fibrosis resolution paradigm.
TNF-like ligand 1 aberrance (TL1A) was found to be able to induce intestinal inflammation and fibrosis.
Furthermore, significantly increased TL1A had been detected in liver tissues and mononuclear cells of patients with primary biliary cirrhosis (PBC).
This study was to investigate the effect of myeloid cells with constitutive TL1A expression on liver fibrogenesis.
We found that TL1A expressions in liver tissues and macrophages were significantly increased in mice with liver fibrosis induced by injection of carbon tetrachloride (CCl4).
TL1A overexpression in myeloid cells induced liver function injury, accelerated the necrosis and apoptosis of hepatocytes, recruited macrophages, and promoted activation of hepatic stellate cells (HSCs) and fibrosis.
In vitro results of our study showed that TL1A overexpression in macrophages promoted secretion of platelet-derived growth factor-BB (PDGF-BB), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β).
Culturing macrophages with TL1A overexpression could accelerate the activation and proliferation of primary HSCs.
These results indicated that constitutive TL1A expression in myeloid cells exacerbated liver fibrosis, probably through macrophage recruitment and secretion of proinflammatory and profibrotic cytokines.
American Psychological Association (APA)
Guo, Jinbo& Luo, Yuxin& Yin, Fengrong& Huo, Xiaoxia& Niu, Guochao& Song, Mei…[et al.]. 2019. Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1180842
Modern Language Association (MLA)
Guo, Jinbo…[et al.]. Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice. Journal of Immunology Research No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1180842
American Medical Association (AMA)
Guo, Jinbo& Luo, Yuxin& Yin, Fengrong& Huo, Xiaoxia& Niu, Guochao& Song, Mei…[et al.]. Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1180842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1180842