Chlorogenic Acid Inhibits BAFF Expression in Collagen-Induced Arthritis and Human Synoviocyte MH7A Cells by Modulating the Activation of the NF-κB Signaling Pathway
Joint Authors
Fu, Xiaohong
Lyu, Xilin
Liu, Han
Zhong, Dan
Xu, Zhizhen
He, Fengtian
Huang, Gang
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
B cell activating factor (BAFF), a member of the tumor necrosis factor (TNF) family, plays a critical role in the pathogenesis and progression of rheumatoid arthritis (RA).
Chlorogenic acid (CGA) is a phenolic compound and exerts antiarthritic activities in arthritis.
However, it is not clear whether the anti-inflammatory property of CGA is associated with the regulation of BAFF expression.
In this study, we found that treatment of the collagen-induced arthritis (CIA) mice with CGA significantly attenuated arthritis progression and markedly inhibited BAFF production in serum as well as the production of serum TNF-α.
Furthermore, CGA inhibits TNF-α-induced BAFF expression in a dose-dependent manner and apoptosis in MH7A cells.
Mechanistically, we found the DNA-binding site for the transcription factor NF-κB in the BAFF promoter region is required for this regulation.
Moreover, CGA reduces the DNA-binding activity of NF-κB to the BAFF promoter region and suppresses BAFF expression through the NF-κB pathway in TNF-α-stimulated MH7A cells.
These results suggest that CGA may serve as a novel therapeutic agent for the treatment of RA by targeting BAFF.
American Psychological Association (APA)
Fu, Xiaohong& Lyu, Xilin& Liu, Han& Zhong, Dan& Xu, Zhizhen& He, Fengtian…[et al.]. 2019. Chlorogenic Acid Inhibits BAFF Expression in Collagen-Induced Arthritis and Human Synoviocyte MH7A Cells by Modulating the Activation of the NF-κB Signaling Pathway. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1180884
Modern Language Association (MLA)
Fu, Xiaohong…[et al.]. Chlorogenic Acid Inhibits BAFF Expression in Collagen-Induced Arthritis and Human Synoviocyte MH7A Cells by Modulating the Activation of the NF-κB Signaling Pathway. Journal of Immunology Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1180884
American Medical Association (AMA)
Fu, Xiaohong& Lyu, Xilin& Liu, Han& Zhong, Dan& Xu, Zhizhen& He, Fengtian…[et al.]. Chlorogenic Acid Inhibits BAFF Expression in Collagen-Induced Arthritis and Human Synoviocyte MH7A Cells by Modulating the Activation of the NF-κB Signaling Pathway. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1180884
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1180884