A Pilot Study of Echinocandin Combination with TrimethoprimSulfamethoxazole and Clindamycin for the Treatment of AIDS Patients with Pneumocystis Pneumonia
Joint Authors
Zhu, Biao
Wang, Mengyan
Lang, Guanjing
Chen, Ying
Hu, Caiqin
Guo, Yongzheng
Tao, Ran
Dong, Xiaotian
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background and Objectives.
Pneumocystis pneumonia (PCP) is a common opportunistic infection in acquired immune deficiency syndrome (AIDS) patients that continues to result in a high mortality rate.
To develop a better treatment strategy and improve PCP prognosis, a cohort study was conducted to evaluate the therapeutic potential of echinocandin treatment for AIDS patients with PCP (AIDS-PCP).
Methods.
The AIDS-PCP patients were analyzed in our retrospective cohort study that were hospitalized in The First Affiliated Hospital of Zhejiang University during 2013–2018.
The antifungal effects of echinocandins were evaluated in two subgroups that were classified by oxygenation as a proxy for the disease state: PaO2/FiO2>200 mmHg and PaO2/FiO2≤200 mmHg.
Intergroup comparisons and survival curves were used to evaluate the effectiveness of the two AIDS-PCP treatment regimens.
Results.
During the follow-up, 182 AIDS-PCP patients were diagnosed and analyzed in the study.
After excluding 55 patients with other superinfections and five patients that were treated with HAART, the remaining 122 patients were enrolled in the study.
The group treated with echinocandins combined with trimethoprim-sulfamethoxazole (TMP-SMZ) and clindamycin exhibited a lower mortality rate (9.62%, 5/52) than did the group with TMP-SMZ and clindamycin treatment (20%, 14/70).
For AIDS-PCP patients in the PaO2/FiO2>200 mmHg subgroup, treatment with echinocandins combined with TMP-SMZ and clindamycin significantly reduced their mortality rate (4.44% (2/45) vs.
18.18% (10/55), P=0.035).
Conclusion.
The results of this study indicate that treatment with echinocandins in combination with the standard TMP-SMZ and clindamycin regimen can improve the prognosis and reduce the mortality rate in patients with mild to moderate AIDS-PCP disease.
American Psychological Association (APA)
Wang, Mengyan& Lang, Guanjing& Chen, Ying& Hu, Caiqin& Guo, Yongzheng& Tao, Ran…[et al.]. 2019. A Pilot Study of Echinocandin Combination with TrimethoprimSulfamethoxazole and Clindamycin for the Treatment of AIDS Patients with Pneumocystis Pneumonia. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1180899
Modern Language Association (MLA)
Wang, Mengyan…[et al.]. A Pilot Study of Echinocandin Combination with TrimethoprimSulfamethoxazole and Clindamycin for the Treatment of AIDS Patients with Pneumocystis Pneumonia. Journal of Immunology Research No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1180899
American Medical Association (AMA)
Wang, Mengyan& Lang, Guanjing& Chen, Ying& Hu, Caiqin& Guo, Yongzheng& Tao, Ran…[et al.]. A Pilot Study of Echinocandin Combination with TrimethoprimSulfamethoxazole and Clindamycin for the Treatment of AIDS Patients with Pneumocystis Pneumonia. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1180899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1180899