DKK2 Impairs Tumor Immunity Infiltration and Correlates with Poor Prognosis in Pancreatic Ductal Adenocarcinoma
Joint Authors
Yang, Jianyu
Jiang, Yongsheng
He, Ruizhe
Liu, Wei
Yang, Minwei
Tao, Lingye
Fu, Xueliang
Shen, Yang
Li, Jiao
Liu, Dejun
Huo, Yanmiao
Zhang, Junfeng
Hua, Rong
Zhang, Zhigang
Sun, Yongwei
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most devastating cancer types despite the improvement of modern medicine.
In our present study, we found that dickkopf-related protein 2 (DKK2) shares a higher expression in PDAC compared with adjacent pancreas tissue in tissue microarray.
In addition, an elevated expression of DKK2 predicts poorer prognosis of patients and positively correlated with poor tumor differentiation.
Multivariate Cox regression analysis was also performed and confirmed that the expression of DKK2 is an independent prognostic factor in PDAC.
A high expression of DKK2 correlates with cell migration and epithelial mesenchymal transition based on gene set enrichment analysis (GSEA) while knockdown of DKK2 in PDAC cells resulted in impaired cellular migration.
Furthermore, GSEA predicts negative correlation between tumor immunity invasion and DKK2 expression.
We then confirmed these results and demonstrated that a higher expression of DKK2 imparts the recruitment of CD8+ T cells.
Our work suggested that DKK2 imparts tumor immune evasion and is associated with poor prognosis in pancreatic ductal adenocarcinoma.
American Psychological Association (APA)
Yang, Jianyu& Jiang, Yongsheng& He, Ruizhe& Liu, Wei& Yang, Minwei& Tao, Lingye…[et al.]. 2019. DKK2 Impairs Tumor Immunity Infiltration and Correlates with Poor Prognosis in Pancreatic Ductal Adenocarcinoma. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1180992
Modern Language Association (MLA)
Yang, Jianyu…[et al.]. DKK2 Impairs Tumor Immunity Infiltration and Correlates with Poor Prognosis in Pancreatic Ductal Adenocarcinoma. Journal of Immunology Research No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1180992
American Medical Association (AMA)
Yang, Jianyu& Jiang, Yongsheng& He, Ruizhe& Liu, Wei& Yang, Minwei& Tao, Lingye…[et al.]. DKK2 Impairs Tumor Immunity Infiltration and Correlates with Poor Prognosis in Pancreatic Ductal Adenocarcinoma. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1180992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1180992