Manipulation of Type I Interferon Signaling by HIV and AIDS-Associated Viruses
Joint Authors
He, Buyuan
Tran, James T.
Sanchez, David Jesse
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Type I Interferons were first described for their profound antiviral abilities in cell culture and animal models, and later, they were translated into potent antiviral therapeutics.
However, as additional studies into the function of Type I Interferons progressed, it was also seen that pathogenic viruses have coevolved to encode potent mechanisms allowing them to evade or suppress the impact of Type I Interferons on their replication.
For chronic viral infections, such as HIV and many of the AIDS-associated viruses, including HTLV, HCV, KSHV, and EBV, the clinical efficacy of Type I Interferons is limited by these mechanisms.
Here, we review some of the ways that HIV and AIDS-associated viruses thrive in Type I Interferon-rich environments via mechanisms that block the function of this important antiviral cytokine.
Overall, a better understanding of these mechanisms creates avenues to better understand the innate immune response to these viruses as well as plan the development of antivirals that would allow the natural antiviral effect of Type I Interferons to manifest during these infections.
American Psychological Association (APA)
He, Buyuan& Tran, James T.& Sanchez, David Jesse. 2019. Manipulation of Type I Interferon Signaling by HIV and AIDS-Associated Viruses. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1181003
Modern Language Association (MLA)
He, Buyuan…[et al.]. Manipulation of Type I Interferon Signaling by HIV and AIDS-Associated Viruses. Journal of Immunology Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1181003
American Medical Association (AMA)
He, Buyuan& Tran, James T.& Sanchez, David Jesse. Manipulation of Type I Interferon Signaling by HIV and AIDS-Associated Viruses. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1181003
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181003