Memory NK Cell Features Exploitable in Anticancer Immunotherapy
Joint Authors
Santoni, Angela
Capuano, Cristina
Pighi, Chiara
Battella, Simone
Palmieri, Gabriella
Galandrini, Ricciarda
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived, hyperfunctional populations, dubbed memory or memory-like NK cells.
Despite significant progress in the field of NK cell-based immunotherapies, some factors including their short life span and the occurrence of a tumor-dependent functional exhaustion have limited their clinical efficacy so that strategies aimed at overcoming these limitations represent one of the main current challenges in the field.
In this scenario, the exploitation of NK cell memory may have a considerable potential.
This article summarizes recent evidence in the literature on the peculiar features that render memory NK cells an attractive tool for antitumor immunotherapy, including their long-term survival and in vivo persistence, the resistance to tumor-dependent immunosuppressive microenvironment, the amplified functional responses to IgG-opsonized tumor cells, and in vitro expansion capability.
Along with highlighting these issues, we speculate that memory NK cell-based adoptive immunotherapy settings would greatly take advantage from the combination with tumor-targeting therapeutic antibodies (mAbs), as a strategy to fully unleash their clinical efficacy.
American Psychological Association (APA)
Capuano, Cristina& Pighi, Chiara& Battella, Simone& Santoni, Angela& Palmieri, Gabriella& Galandrini, Ricciarda. 2019. Memory NK Cell Features Exploitable in Anticancer Immunotherapy. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1181017
Modern Language Association (MLA)
Capuano, Cristina…[et al.]. Memory NK Cell Features Exploitable in Anticancer Immunotherapy. Journal of Immunology Research No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1181017
American Medical Association (AMA)
Capuano, Cristina& Pighi, Chiara& Battella, Simone& Santoni, Angela& Palmieri, Gabriella& Galandrini, Ricciarda. Memory NK Cell Features Exploitable in Anticancer Immunotherapy. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1181017
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181017