Shared Medical and Environmental Risk Factors in Dry Eye Syndrome, Sjogren’s Syndrome, and B-Cell Non-Hodgkin Lymphoma: A Case-Control Study
Joint Authors
Ben-Eli, Hadas
Aframian, Doron J.
Ben-Chetrit, Eldad
Mevorach, Dror
Kleinstern, Geffen
Paltiel, Ora
Solomon, Abraham
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
To assess whether there are shared exposures associated with Sjogren’s syndrome (SS), dry eye syndrome (DES), and B-cell non-Hodgkin lymphoma (B-NHL), in order to determine whether they are etiologically related.
Methods.
In a clinic-based case-control study, 702 participants (91 SS, 120 DES, 211 (age and sex frequency-matched) controls, and 280 B-NHL cases) were recruited and interviewed regarding exposures, medical history, and family history.
Results.
Female predominance was noted in SS (ratio 9.2 : 1).
Eye dryness was severest in SS compared to DES and controls (P<0.001).
Compared to controls, alcohol consumption was inversely associated with NHL, DES, and SS (odds ratio OR=0.47, 95% confidence interval (CI): 0.31-0.71; OR=0.54, 95% CI: 0.33-0.88; and OR=0.26, 95% CI: 0.14-0.49, respectively), while a previous history of infection requiring hospitalization was positively associated with all three conditions: NHL (OR=1.92; 95% CI: 1.23-2.99), DES (OR=3.29; 95% CI: 1.97-5.47), and SS (OR=4.74; 95% CI: 2.66-8.44).
NHL patients were more likely to report first-degree relatives with hematologic cancer, while having first-degree relatives with an autoimmune disease (AID) was associated with SS (OR=5.25; 95% CI: 2.59-10.63) and DES (OR=3.55; 95% CI: 1.83-6.91) compared to controls.
Conclusions.
Some exposures are associated with all three conditions (such as an inverse association with alcohol consumption and a positive association with serious past infection), while a family history of AID appears to be shared by DES and SS, but not NHL subjects.
Shared risk factors for all three conditions indicate possible mutual etiological pathways.
American Psychological Association (APA)
Ben-Eli, Hadas& Aframian, Doron J.& Ben-Chetrit, Eldad& Mevorach, Dror& Kleinstern, Geffen& Paltiel, Ora…[et al.]. 2019. Shared Medical and Environmental Risk Factors in Dry Eye Syndrome, Sjogren’s Syndrome, and B-Cell Non-Hodgkin Lymphoma: A Case-Control Study. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1181037
Modern Language Association (MLA)
Ben-Eli, Hadas…[et al.]. Shared Medical and Environmental Risk Factors in Dry Eye Syndrome, Sjogren’s Syndrome, and B-Cell Non-Hodgkin Lymphoma: A Case-Control Study. Journal of Immunology Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1181037
American Medical Association (AMA)
Ben-Eli, Hadas& Aframian, Doron J.& Ben-Chetrit, Eldad& Mevorach, Dror& Kleinstern, Geffen& Paltiel, Ora…[et al.]. Shared Medical and Environmental Risk Factors in Dry Eye Syndrome, Sjogren’s Syndrome, and B-Cell Non-Hodgkin Lymphoma: A Case-Control Study. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1181037
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181037