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Neutrophil-Derived MRP14 Supports Plasma Cell Commitment and Protects Myeloma Cells from Apoptosis
Joint Authors
Cao, Weidong
Song, Jian
Zhao, Zhihong
Yang, Qian
Luo, Zhonghua
Chang, Hongbo
Liu, Pengcheng
Li, Zhichao
Guo, Shengli
Zhou, Chunhui
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Neutrophils have recently been proposed as cells with high functional plasticity and are involved in the pathogenesis of infections, malignancy, and autoimmune diseases.
However, less is known about the role of neutrophil in humoral response.
In this study, we examined the importance of neutrophils and the neutrophil-derived DAMP protein, MRP14, in antibody production.
Splenic neutrophils and MRP14 that are present in the splenic peri-MZ region have a close contact with MZ B cells and promote their differentiation into plasma cells.
Using neutrophil-depleting mice and an MRP14-blocking compound, we showed that the presence of neutrophil and MRP14 is required for class switch, plasma cell maintenance, and antibody production in the spleen.
We found that MRP14 could also be produced by neutrophils in the bone marrow and support the maintenance of bone marrow plasma cells.
MRP14 binding could enhance the effect of the BAFF signal and protect primary multiple myeloma cells from doxorubicin-induced apoptosis.
Our data demonstrate the effects of neutrophils on neighboring B cells and plasma cells, which provides new insights into the connection between neutrophil and humoral responses.
American Psychological Association (APA)
Zhao, Zhihong& Luo, Zhonghua& Yang, Qian& Chang, Hongbo& Liu, Pengcheng& Li, Zhichao…[et al.]. 2019. Neutrophil-Derived MRP14 Supports Plasma Cell Commitment and Protects Myeloma Cells from Apoptosis. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1181091
Modern Language Association (MLA)
Zhao, Zhihong…[et al.]. Neutrophil-Derived MRP14 Supports Plasma Cell Commitment and Protects Myeloma Cells from Apoptosis. Journal of Immunology Research No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1181091
American Medical Association (AMA)
Zhao, Zhihong& Luo, Zhonghua& Yang, Qian& Chang, Hongbo& Liu, Pengcheng& Li, Zhichao…[et al.]. Neutrophil-Derived MRP14 Supports Plasma Cell Commitment and Protects Myeloma Cells from Apoptosis. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1181091
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181091