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Anti-Skin Cancer Activities of Apostichopus japonicus Extracts from Low-Temperature Ultrasonification Process
Joint Authors
Kim, Nam Young
Kang, Do Hyung
Heo, Soo Jin
Lee, Hyeon Yong
Choi, Woon Yong
Source
Journal of Healthcare Engineering
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
This work aimed to enhance anti-skin cancer activities of Apostichopus japonicus, spiky sea cucumber, through ultrasonification extraction process at low temperature.
Methods.
Dried Apostichopus japonicus was extracted with an ultrasonification process at 50°C and 95 kHz for two hours (UE), and anti-skin cancer activities of the extract from the UE were also compared with those from conventional extraction processes using hot water (WE) or 70% ethanol at 80°C (EE) for 12 hours.
Results.
The amount of canthaxanthin in the UE was higher than that in the WE or EE, and its cytotoxicity against human keratinocytes was less than the others.
The extract from the UE showed 93.5% inhibition against human malignant cell growth, which was also higher than those from both WE and EE.
The extract from the UE demonstrated the ability of inhibiting both cancer cell proliferation and metastasis by downregulating the skin tumor-promoting genes such as Bcl-2, STAT3, and MMP-9.
Conclusions.
The ultrasonification process was proved to be effective especially in extracting heat-sensitive marine biomass, A.
japonicus having higher amounts of canthaxanthin and better anti-skin cancer activities, possibly due to less destruction and high elution of bioactive substances under low temperature extraction condition.
American Psychological Association (APA)
Kim, Nam Young& Choi, Woon Yong& Heo, Soo Jin& Kang, Do Hyung& Lee, Hyeon Yong. 2017. Anti-Skin Cancer Activities of Apostichopus japonicus Extracts from Low-Temperature Ultrasonification Process. Journal of Healthcare Engineering،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1181143
Modern Language Association (MLA)
Kim, Nam Young…[et al.]. Anti-Skin Cancer Activities of Apostichopus japonicus Extracts from Low-Temperature Ultrasonification Process. Journal of Healthcare Engineering No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1181143
American Medical Association (AMA)
Kim, Nam Young& Choi, Woon Yong& Heo, Soo Jin& Kang, Do Hyung& Lee, Hyeon Yong. Anti-Skin Cancer Activities of Apostichopus japonicus Extracts from Low-Temperature Ultrasonification Process. Journal of Healthcare Engineering. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1181143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181143