Early Real-World Experience with CoreValve Evolut PRO and R Systems for Transcatheter Aortic Valve Replacement
Joint Authors
Rao, Gaurav
Sheth, Shikha
Donnelly, Joseph
Scatola, Andrew
Tariq, Umair
Laighold, Saaron
Grines, Cindy
Rutkin, Bruce
Source
Journal of Interventional Cardiology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
The purpose of this study was to compare the efficacy and safety of the Evolut PRO to the Evolut R valve in a real-world setting.
Background.
The next-generation self-expanding transcatheter aortic valve replacement (TAVR) system, the CoreValve Evolut PRO was designed with an outer pericardial skirt to improve valve-sealing performance.
Safety and efficacy of this valve have not previously been compared to its predecessor, the Evolut R valve.
Methods.
We retrospectively studied 134 patients who underwent TAVR with the Evolut PRO or Evolut R valve over one year at a tertiary center.
Endpoints, defined by the Valve Academic Research Consortium-2 criteria, included device success, paravalvular leak (PVL), and a composite safety endpoint including mortality, stroke, major vascular complications, life-threatening bleeding, acute kidney injury, coronary artery obstruction, and repeat procedure for valve-related dysfunction.
Results.
60 Evolut PRO and 56 Evolut R patients met the study criteria.
Both groups had similar device success rates (90 vs.
89%, p=0.44).
Incidence of moderate PVL was similar on discharge (5 vs.
11%, p=0.68) and at 30 days (11 vs.
13%, p=0.79), with nil incidence of severe PVL.
There were no mortalities, and the VARC-2 safety endpoint at 30 days was comparable.
Conclusion.
Despite the additional pericardial skirt and larger sheath size of Evolut PRO, outcomes were comparable between the two Evolut systems, supporting adoption of the newest generation valve in the management of severe aortic stenosis as well as continued use of the Evolut R in patients with smaller vasculature warranting a lower profile device.
American Psychological Association (APA)
Rao, Gaurav& Sheth, Shikha& Donnelly, Joseph& Scatola, Andrew& Tariq, Umair& Laighold, Saaron…[et al.]. 2019. Early Real-World Experience with CoreValve Evolut PRO and R Systems for Transcatheter Aortic Valve Replacement. Journal of Interventional Cardiology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1181189
Modern Language Association (MLA)
Rao, Gaurav…[et al.]. Early Real-World Experience with CoreValve Evolut PRO and R Systems for Transcatheter Aortic Valve Replacement. Journal of Interventional Cardiology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1181189
American Medical Association (AMA)
Rao, Gaurav& Sheth, Shikha& Donnelly, Joseph& Scatola, Andrew& Tariq, Umair& Laighold, Saaron…[et al.]. Early Real-World Experience with CoreValve Evolut PRO and R Systems for Transcatheter Aortic Valve Replacement. Journal of Interventional Cardiology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1181189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181189