Distant Supervision with Transductive Learning for Adverse Drug Reaction Identification from Electronic Medical Records
Joint Authors
Taewijit, Siriwon
Theeramunkong, Thanaruk
Ikeda, Mitsuru
Source
Journal of Healthcare Engineering
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-26
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Information extraction and knowledge discovery regarding adverse drug reaction (ADR) from large-scale clinical texts are very useful and needy processes.
Two major difficulties of this task are the lack of domain experts for labeling examples and intractable processing of unstructured clinical texts.
Even though most previous works have been conducted on these issues by applying semisupervised learning for the former and a word-based approach for the latter, they face with complexity in an acquisition of initial labeled data and ignorance of structured sequence of natural language.
In this study, we propose automatic data labeling by distant supervision where knowledge bases are exploited to assign an entity-level relation label for each drug-event pair in texts, and then, we use patterns for characterizing ADR relation.
The multiple-instance learning with expectation-maximization method is employed to estimate model parameters.
The method applies transductive learning to iteratively reassign a probability of unknown drug-event pair at the training time.
By investigating experiments with 50,998 discharge summaries, we evaluate our method by varying large number of parameters, that is, pattern types, pattern-weighting models, and initial and iterative weightings of relations for unlabeled data.
Based on evaluations, our proposed method outperforms the word-based feature for NB-EM (iEM), MILR, and TSVM with F1 score of 11.3%, 9.3%, and 6.5% improvement, respectively.
American Psychological Association (APA)
Taewijit, Siriwon& Theeramunkong, Thanaruk& Ikeda, Mitsuru. 2017. Distant Supervision with Transductive Learning for Adverse Drug Reaction Identification from Electronic Medical Records. Journal of Healthcare Engineering،Vol. 2017, no. 2017, pp.1-21.
https://search.emarefa.net/detail/BIM-1181190
Modern Language Association (MLA)
Taewijit, Siriwon…[et al.]. Distant Supervision with Transductive Learning for Adverse Drug Reaction Identification from Electronic Medical Records. Journal of Healthcare Engineering No. 2017 (2017), pp.1-21.
https://search.emarefa.net/detail/BIM-1181190
American Medical Association (AMA)
Taewijit, Siriwon& Theeramunkong, Thanaruk& Ikeda, Mitsuru. Distant Supervision with Transductive Learning for Adverse Drug Reaction Identification from Electronic Medical Records. Journal of Healthcare Engineering. 2017. Vol. 2017, no. 2017, pp.1-21.
https://search.emarefa.net/detail/BIM-1181190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181190