Distant Supervision with Transductive Learning for Adverse Drug Reaction Identification from Electronic Medical Records

Joint Authors

Taewijit, Siriwon
Theeramunkong, Thanaruk
Ikeda, Mitsuru

Source

Journal of Healthcare Engineering

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-21, 21 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-09-26

Country of Publication

Egypt

No. of Pages

21

Main Subjects

Public Health
Medicine

Abstract EN

Information extraction and knowledge discovery regarding adverse drug reaction (ADR) from large-scale clinical texts are very useful and needy processes.

Two major difficulties of this task are the lack of domain experts for labeling examples and intractable processing of unstructured clinical texts.

Even though most previous works have been conducted on these issues by applying semisupervised learning for the former and a word-based approach for the latter, they face with complexity in an acquisition of initial labeled data and ignorance of structured sequence of natural language.

In this study, we propose automatic data labeling by distant supervision where knowledge bases are exploited to assign an entity-level relation label for each drug-event pair in texts, and then, we use patterns for characterizing ADR relation.

The multiple-instance learning with expectation-maximization method is employed to estimate model parameters.

The method applies transductive learning to iteratively reassign a probability of unknown drug-event pair at the training time.

By investigating experiments with 50,998 discharge summaries, we evaluate our method by varying large number of parameters, that is, pattern types, pattern-weighting models, and initial and iterative weightings of relations for unlabeled data.

Based on evaluations, our proposed method outperforms the word-based feature for NB-EM (iEM), MILR, and TSVM with F1 score of 11.3%, 9.3%, and 6.5% improvement, respectively.

American Psychological Association (APA)

Taewijit, Siriwon& Theeramunkong, Thanaruk& Ikeda, Mitsuru. 2017. Distant Supervision with Transductive Learning for Adverse Drug Reaction Identification from Electronic Medical Records. Journal of Healthcare Engineering،Vol. 2017, no. 2017, pp.1-21.
https://search.emarefa.net/detail/BIM-1181190

Modern Language Association (MLA)

Taewijit, Siriwon…[et al.]. Distant Supervision with Transductive Learning for Adverse Drug Reaction Identification from Electronic Medical Records. Journal of Healthcare Engineering No. 2017 (2017), pp.1-21.
https://search.emarefa.net/detail/BIM-1181190

American Medical Association (AMA)

Taewijit, Siriwon& Theeramunkong, Thanaruk& Ikeda, Mitsuru. Distant Supervision with Transductive Learning for Adverse Drug Reaction Identification from Electronic Medical Records. Journal of Healthcare Engineering. 2017. Vol. 2017, no. 2017, pp.1-21.
https://search.emarefa.net/detail/BIM-1181190

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1181190