Delayed PCI 12 Hours after the Onset of Symptoms Is Associated with Improved Outcomes for Patients with ST-Segment Elevation Myocardial Infarction: A Real-World Study
Joint Authors
Zheng, Ying-Ying
Ma, Yi-Tong
Xie, Xiang
Xiu, Wen-Juan
Yang, Hai-Tao
Source
Journal of Interventional Cardiology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Primary percutaneous coronary intervention (PPCI) plays a pivotal role in the treatment of ST-segment elevation myocardial infarction (STEMI).
However, it remains controversial whether PCI delayed beyond the recommended time window of 12 h after the onset of symptoms is applicable to STEMI.
Objective.
The acute myocardial infarction (AMI) registration study in Xinjiang, China, is a real-world clinical trial (retrospective cohort study) that includes hospitalized patients.
The purpose of this study was to compare delayed PCI and medication therapy beyond the recommended time window of 12 h after the onset of symptoms on the outcomes of STEMI patients.
Methods and Results.
From May 2012 to December 2015, a total of 1072 STEMI patients received delayed PCI (n=594) or standard medication therapy (MT) (n=478) more than 12 h after the onset of symptoms.
The number of all-cause deaths in the delayed PCI group and that in the MT group were 55 (9.3%) and 138 (28.9%), respectively, and a significant difference between the groups was indicated for this variable (P<0.001).
The number of cardiac deaths in the delayed PCI group and that in the medication therapy group were 47 (7.9%) and 120 (25.1%), respectively, and a significant difference between the groups was indicated for this variable (P<0.001).
We also found that the MACE incidence in the delayed PCI group was significantly higher than it was in the MT group (32.2% versus 43.5%, P<0.001).
Propensity score matching (PSM) analyses remained significant differences between the delayed PCI group and the MT group, respectively, in all-cause deaths (9.3% versus 25.8%, P<0.001) and cardiac death (8.7% versus 21.6%, P<0.001).
Conclusion.
Compared to medication therapy, PCI for STEMI delayed beyond 12 h after the onset of symptoms can better reduce mortality and the incidence of MACEs.
Trial Registration.
This study is registered with the following: Trial Registration: clinicaltrials.gov; Identifier: NCT02737956.
American Psychological Association (APA)
Xiu, Wen-Juan& Yang, Hai-Tao& Zheng, Ying-Ying& Ma, Yi-Tong& Xie, Xiang. 2019. Delayed PCI 12 Hours after the Onset of Symptoms Is Associated with Improved Outcomes for Patients with ST-Segment Elevation Myocardial Infarction: A Real-World Study. Journal of Interventional Cardiology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1181194
Modern Language Association (MLA)
Xiu, Wen-Juan…[et al.]. Delayed PCI 12 Hours after the Onset of Symptoms Is Associated with Improved Outcomes for Patients with ST-Segment Elevation Myocardial Infarction: A Real-World Study. Journal of Interventional Cardiology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1181194
American Medical Association (AMA)
Xiu, Wen-Juan& Yang, Hai-Tao& Zheng, Ying-Ying& Ma, Yi-Tong& Xie, Xiang. Delayed PCI 12 Hours after the Onset of Symptoms Is Associated with Improved Outcomes for Patients with ST-Segment Elevation Myocardial Infarction: A Real-World Study. Journal of Interventional Cardiology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1181194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181194