![](/images/graphics-bg.png)
Drug Coated Balloon-Only Strategy in De Novo Lesions of Large Coronary Vessels
Joint Authors
Bento, Angela Pimenta
Frey, Norbert
Krackhardt, Florian
Waliszewski, Matthias W.
Wan Ahmad, Wan Azman
Rosenberg, Mark
Chin, Kenneth
Caramanno, Giuseppe
Milazzo, Diego
Nuruddin, Amin Ariff
Liew, Houng Bang
Macia, Jean-Christophe
Maskon, Oteh
Source
Journal of Interventional Cardiology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
We analyzed the efficacy of drug coated balloons (DCB) as a stand-alone-therapy in de novo lesions of large coronary arteries.
DCBs seem to be an attractive alternative for the stent-free interventional treatment of de novo coronary artery disease (CAD).
However, data regarding a DCB-only approach in de novo CAD are currently limited to vessels of small caliber.
Methods.
By means of propensity score (PS) matching 234 individuals with de novo CAD were identified with similar demographic characteristics.
This patient population was stratified in a 1:1 fashion according to a reference vessel diameter cut-off of 2.75 mm in small and large vessel disease.
The primary endpoint was the rate of clinically driven target lesion revascularization (TLR) at 9 months.
Results.
Patients with small vessel disease had an average reference diameter of 2.45 ± 0.23 mm, while the large vessel group averaged 3.16 ± 0.27 mm.
Regarding 9-month major adverse cardiac event (MACE), 5.7% of the patients with small and 6.1% of the patients with large vessels had MACE (p=0.903).
Analysis of the individual MACE components revealed a TLR rate of 3.8% in small and 1.0% in large vessels (p=0.200).
Of note, no thrombotic events in the DCB treated coronary segments occurred in either group during the 9-month follow-up.
Conclusions.
Our data demonstrate for the first time that DCB-only PCI of de novo lesions in large coronary arteries (>2.75 mm) is safe and as effective.
Interventional treatment for CAD without permanent or temporary scaffolding, demonstrated a similar efficacy for large and small vessels.
American Psychological Association (APA)
Rosenberg, Mark& Waliszewski, Matthias W.& Krackhardt, Florian& Chin, Kenneth& Wan Ahmad, Wan Azman& Caramanno, Giuseppe…[et al.]. 2019. Drug Coated Balloon-Only Strategy in De Novo Lesions of Large Coronary Vessels. Journal of Interventional Cardiology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1181253
Modern Language Association (MLA)
Rosenberg, Mark…[et al.]. Drug Coated Balloon-Only Strategy in De Novo Lesions of Large Coronary Vessels. Journal of Interventional Cardiology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1181253
American Medical Association (AMA)
Rosenberg, Mark& Waliszewski, Matthias W.& Krackhardt, Florian& Chin, Kenneth& Wan Ahmad, Wan Azman& Caramanno, Giuseppe…[et al.]. Drug Coated Balloon-Only Strategy in De Novo Lesions of Large Coronary Vessels. Journal of Interventional Cardiology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1181253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181253