Left Atrial Appendage Occlusion in High Bleeding Risk Patients
Joint Authors
Delitala, Alessandro P.
Merella, Pierluigi
Lorenzoni, Giovanni
Sechi, Filomena
Decandia, Federica
Viola, Graziana
Berne, Paola
Deiana, Gianluca
Mazzone, Patrizio
Casu, Gavino
Source
Journal of Interventional Cardiology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
The aim of this study was to investigate the outcomes of left atrial appendage occlusion (LAAO) in high bleeding risk patients suffering atrial fibrillation (AF) and to analyze the different antithrombotic therapies following the intervention.
Background.
Methods.
This monocentric study included 68 patients with nonvalvular AF with an absolute contraindication to OAT or at high bleeding risk.
Follow-up was done with a clinical visit at 3-6-12 months.
Results.
Successful LAAO was achieved in 67/68 patients.
At discharge, 32/68 patients were on dual antiplatelet therapy (APT), 34/68 were without any antithrombotic therapy or with a single antiplatelet drug, and 2/68 were on anticoagulant therapy.
At three-month follow-up visit, 73.6% of the patients did not receive dual APT, of whom 14.7% had no thrombotic therapy and 58.9% were on single antiplatelet therapy.
During a follow-up of 1.4 ± 0.9 years, 3/62 patients had late adverse effects (2 device-related thrombus without clinical consequences and 1 extracranial bleeding).
The device-related thrombosis was not related to the antithrombotic therapy.
Conclusions.
LAAO is feasible and safe and prevents stroke in patients with AF with contraindication to oral anticoagulant therapy.
After LAAO, single antiplatelet therapy seems to be a safe alternative to dual antiplatelet therapy, especially in patients at high bleeding risk.
No benefit has been observed with dual APT.
American Psychological Association (APA)
Merella, Pierluigi& Lorenzoni, Giovanni& Delitala, Alessandro P.& Sechi, Filomena& Decandia, Federica& Viola, Graziana…[et al.]. 2019. Left Atrial Appendage Occlusion in High Bleeding Risk Patients. Journal of Interventional Cardiology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1181257
Modern Language Association (MLA)
Merella, Pierluigi…[et al.]. Left Atrial Appendage Occlusion in High Bleeding Risk Patients. Journal of Interventional Cardiology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1181257
American Medical Association (AMA)
Merella, Pierluigi& Lorenzoni, Giovanni& Delitala, Alessandro P.& Sechi, Filomena& Decandia, Federica& Viola, Graziana…[et al.]. Left Atrial Appendage Occlusion in High Bleeding Risk Patients. Journal of Interventional Cardiology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1181257
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181257