Anti-Inflammatory Compounds from Vietnamese Piper bavinum
Joint Authors
Huu Tung, Nguyen
Min, Byung Sun
Hoang, Viet Dung
Nguyen, Phi Hung
Doan, Minh Thu
Tran, Manh Hung
Huynh, Nhu Tuan
To, Dao Cuong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study reports the anti-inflammatory activity-guided fractionation of the aerial part of Piper bavinum C.
CD.
(Piperaceae) that led to the isolation of eight secondary metabolites (1–8).
The chemical structures of 1–8 were established mainly by NMR and mass spectra.
Compound 5 was isolated from P.
bavinum for the first time.
All the isolated compounds were evaluated against LPS-induced NO production in macrophage RAW 264.7 cells in vitro.
Among them, compound 4 showed the most potent inhibitory activity against the LPS-induced NO production with an IC50 value of 5.2 μM followed by compound 5 that inhibited NO production with an IC50 value of 13.5 μM.
In the protein levels, compound 4 suppressed LPS-induced COX-2 and iNOS expressions in a dose-dependent manner.
The results suggested that P.
bavinum and its constituents might exert anti-inflammatory effects.
American Psychological Association (APA)
Hoang, Viet Dung& Nguyen, Phi Hung& Doan, Minh Thu& Tran, Manh Hung& Huynh, Nhu Tuan& Huu Tung, Nguyen…[et al.]. 2020. Anti-Inflammatory Compounds from Vietnamese Piper bavinum. Journal of Chemistry،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1181283
Modern Language Association (MLA)
Hoang, Viet Dung…[et al.]. Anti-Inflammatory Compounds from Vietnamese Piper bavinum. Journal of Chemistry No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1181283
American Medical Association (AMA)
Hoang, Viet Dung& Nguyen, Phi Hung& Doan, Minh Thu& Tran, Manh Hung& Huynh, Nhu Tuan& Huu Tung, Nguyen…[et al.]. Anti-Inflammatory Compounds from Vietnamese Piper bavinum. Journal of Chemistry. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1181283
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181283