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One-Year Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement for Stenotic Bicuspid versus Tricuspid Aortic Valves: A Meta-Analysis and Meta-Regression
Joint Authors
Monlezun, Dominique J.
Quintana, Raymundo A.
DaSilva-DeAbreu, Adrian
Sandhu, Uday G.
Okwan-Duodu, Derick
Ramírez, Jonanlis
Denktas, Ali E.
Jneid, Hani
Paniagua, David
Source
Journal of Interventional Cardiology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
To assess 1-year mortality after transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic stenosis (AS).
Background.
Clinical trials have proven the beneficial effect of TAVR on mortality in patients with tricuspid AS.
Individuals with bicuspid AS were excluded from these trials.
Methods.
A meta-analysis using literature search from the Cochrane, PubMed, ClinicalTrials, SCOPUS, and EMBASE databases was conducted to determine the effect of TAVR on 1-year mortality in patients with bicuspid AS.
Short-term outcomes that could potentially impact one-year mortality were analyzed.
Results.
After evaluating 380 potential articles, 5 observational studies were selected.
A total of 3890 patients treated with TAVR were included: 721 had bicuspid and 3,169 had tricuspid AS.
No statistically significant difference between the baseline characteristics of the two groups of patients was seen outside of mean aortic gradient.
Our primary endpoint of one-year all-cause mortality revealed 85 deaths in 719 patients (11.82%) with bicuspid AS compared to 467 deaths in 3100 patients (15.06%) with tricuspid AS, with no difference between both groups [relative risk (RR) 1.03; 95% CI 0.70-1.51].
Patients with bicuspid AS were associated with a decrease in device success (RR 0.62; 95% CI 0.45-0.84) and an increase in moderate-to-severe prosthetic valve regurgitation (RR 1.55; 95% CI 1.07-2.22) after TAVR compared to patients with tricuspid AS.
The effect of meta-regression coefficients on one-year all-cause mortality was not statistically significant for any patient baseline characteristics.
Conclusion.
When comparing TAVR procedure in tricuspid AS versus bicuspid AS, there was no difference noted in one-year all-cause mortality.
American Psychological Association (APA)
Quintana, Raymundo A.& Monlezun, Dominique J.& DaSilva-DeAbreu, Adrian& Sandhu, Uday G.& Okwan-Duodu, Derick& Ramírez, Jonanlis…[et al.]. 2019. One-Year Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement for Stenotic Bicuspid versus Tricuspid Aortic Valves: A Meta-Analysis and Meta-Regression. Journal of Interventional Cardiology،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1181286
Modern Language Association (MLA)
Quintana, Raymundo A.…[et al.]. One-Year Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement for Stenotic Bicuspid versus Tricuspid Aortic Valves: A Meta-Analysis and Meta-Regression. Journal of Interventional Cardiology No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1181286
American Medical Association (AMA)
Quintana, Raymundo A.& Monlezun, Dominique J.& DaSilva-DeAbreu, Adrian& Sandhu, Uday G.& Okwan-Duodu, Derick& Ramírez, Jonanlis…[et al.]. One-Year Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement for Stenotic Bicuspid versus Tricuspid Aortic Valves: A Meta-Analysis and Meta-Regression. Journal of Interventional Cardiology. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1181286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181286