Inflammation-Related MicroRNAs Are Associated with Plaque Stability Calculated by IVUS in Coronary Heart Disease Patients
Joint Authors
Zhu, Guo-fu
Chu, Tianshu
Ruan, Zhimin
Zhang, Mingguo
Zhou, Mingli
Zhang, Qian
Zhang, Ran
Wu, Liyong
Source
Journal of Interventional Cardiology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
This study aimed to investigate the association between inflammation-related microRNAs (miR-21, 146a, 155) and the plaque stability in coronary artery disease patients.
Methods.
The expression of miR-21, 146a, and 155 was measured by real-time PCR in 310 consecutive patients.
The level of hs-CRP, IL-6, and IL-8 was measured by ELISA.
The plaque stability of coronary stenotic lesions was evaluated with intravascular ultrasound (IVUS).
Results.
(1) The levels of hs-CRP, IL-6, and IL-8 were significantly increased in the UAP and AMI groups compared with the CPS group (P<0.01).
(2) The expression of miR-21 and miR-146a in peripheral blood mononuclear cells (PBMCs) and plasma was significantly higher in CAD patients compared with non-CAD patients, whereas the miR-155 expression in PBMCs and plasma was significantly lower in patients with CAD.
(3) The miR-21 expression in PBMCs was higher in UAP and AMI groups compared with CPS group.
The miR-146a expression in PBMCs was higher in SAP, UAP, and AMI groups than in CPS group.
Although the level of miR-155 in PBMCs was lower in SAP, UAP, and AMI groups than in CPS group.
The expression patterns of miR-21, miR-146a, and miR-155 in plasma were consistent with those of PBMCs.
(4) The expressions of miR-21 and miR-146a in PBMCs and plasma were significantly higher in the vulnerable plaque group than those in stable plaque group.
While miR-155 in PBMCs and plasma was significantly lower in vulnerable plaque group compared with stable plaque group.
(5) The levels of miR-21 and miR-146a in PBMCs and plasma were significantly higher in soft plaque group than in fibrous plaque group and calcified plaque group.
However, miR-155 in PBMCs and plasma was significantly lower in soft plaque group.
Conclusions.
The expression of miR-21 and miR-146a are associated with the plaque stability in coronary stenotic lesions, whereas miR-155 expression is inversely associated with the plaque stability.
American Psychological Association (APA)
Zhu, Guo-fu& Chu, Tianshu& Ruan, Zhimin& Zhang, Mingguo& Zhou, Mingli& Zhang, Qian…[et al.]. 2019. Inflammation-Related MicroRNAs Are Associated with Plaque Stability Calculated by IVUS in Coronary Heart Disease Patients. Journal of Interventional Cardiology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1181307
Modern Language Association (MLA)
Zhu, Guo-fu…[et al.]. Inflammation-Related MicroRNAs Are Associated with Plaque Stability Calculated by IVUS in Coronary Heart Disease Patients. Journal of Interventional Cardiology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1181307
American Medical Association (AMA)
Zhu, Guo-fu& Chu, Tianshu& Ruan, Zhimin& Zhang, Mingguo& Zhou, Mingli& Zhang, Qian…[et al.]. Inflammation-Related MicroRNAs Are Associated with Plaque Stability Calculated by IVUS in Coronary Heart Disease Patients. Journal of Interventional Cardiology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1181307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181307