Synthesis and Biological Activity of 2-Arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides
Joint Authors
Zhao, Shengxian
Cao, Yin
Cui, Zhenzhen
Zhang, Jiayun
Pan, Zhixiang
Hu, Hongyu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A series of 2-arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides 5a–5o were synthesized and characterized.
The synthesized compounds (5a–5o) were screened in vitro against three breast cancer cell lines: SKBR3, MDA-MB-231, and MCF-7 cancer cell lines by the MTT assay.
According to MTT results, compounds 5k and 5l showed better antiproliferative activities over MCF-7 cell lines with IC50 values of 8.50 and 12.51 μM.
Colony formation assay indicated 5k/5l treatment obviously inhibited the growth of MCF-7 cells and 5k/5l-induced cell cycle was arrested in the G2-M phase.
Moreover, 5k/5l significantly increased the level of cleaved PARP and induced the apoptosis in MCF-7 cells.
In addition, compared to Hela cells, MCF-7 cells were more sensitive to 5k/5l treatment.
American Psychological Association (APA)
Zhao, Shengxian& Cao, Yin& Cui, Zhenzhen& Zhang, Jiayun& Pan, Zhixiang& Hu, Hongyu. 2020. Synthesis and Biological Activity of 2-Arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides. Journal of Chemistry،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1181491
Modern Language Association (MLA)
Zhao, Shengxian…[et al.]. Synthesis and Biological Activity of 2-Arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides. Journal of Chemistry No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1181491
American Medical Association (AMA)
Zhao, Shengxian& Cao, Yin& Cui, Zhenzhen& Zhang, Jiayun& Pan, Zhixiang& Hu, Hongyu. Synthesis and Biological Activity of 2-Arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides. Journal of Chemistry. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1181491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181491