Synthesis and Antimicrobial Resistant Modulatory Activity of 2,4-Dinitrophenylhydrazone Derivatives as Agents against Some ESKAPE Human Pathogens

Joint Authors

Amengor, Cedric D. K.
Ade, Alberta
Brobbey, Abena
Ayensu, Isaac
Harley, Benjamin K.
Boakye, Yaw Duah

Source

Journal of Chemistry

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-10-07

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Chemistry

Abstract EN

A library of six novel phenylhydrazones were synthesized and evaluated for their in vitro antimicrobial and resistance modulating activity against a panel of Gram-positive, Gram-negative, and fungal species.

The compounds were produced in good yields of 60–92% w/w and characterized using melting point, UV-visible spectroscopy, infrared, and nuclear magnetic resonance (1H, 13C, and DEPT-Q) techniques.

Mass spectroscopy was used to confirm the identity of one of the most active compounds, 5 [SA5].

The phenylhydrazones showed activity against all the six selected microorganisms with minimum inhibitory concentration (MIC) values of the most active compounds, 1 [BP1] and 5 [SA5], at 138 µM (Klebsiella pneumoniae) and 165 µM (Streptococcus pneumoniae), respectively.

Compound 1 [BP1] further demonstrated a high resistance modulatory activity at 1.078 µM against Streptococcus pneumoniae and Klebsiella pneumoniae.

American Psychological Association (APA)

Ade, Alberta& Amengor, Cedric D. K.& Brobbey, Abena& Ayensu, Isaac& Harley, Benjamin K.& Boakye, Yaw Duah. 2020. Synthesis and Antimicrobial Resistant Modulatory Activity of 2,4-Dinitrophenylhydrazone Derivatives as Agents against Some ESKAPE Human Pathogens. Journal of Chemistry،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1181529

Modern Language Association (MLA)

Ade, Alberta…[et al.]. Synthesis and Antimicrobial Resistant Modulatory Activity of 2,4-Dinitrophenylhydrazone Derivatives as Agents against Some ESKAPE Human Pathogens. Journal of Chemistry No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1181529

American Medical Association (AMA)

Ade, Alberta& Amengor, Cedric D. K.& Brobbey, Abena& Ayensu, Isaac& Harley, Benjamin K.& Boakye, Yaw Duah. Synthesis and Antimicrobial Resistant Modulatory Activity of 2,4-Dinitrophenylhydrazone Derivatives as Agents against Some ESKAPE Human Pathogens. Journal of Chemistry. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1181529

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1181529