Synthesis and Antimicrobial Resistant Modulatory Activity of 2,4-Dinitrophenylhydrazone Derivatives as Agents against Some ESKAPE Human Pathogens
Joint Authors
Amengor, Cedric D. K.
Ade, Alberta
Brobbey, Abena
Ayensu, Isaac
Harley, Benjamin K.
Boakye, Yaw Duah
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A library of six novel phenylhydrazones were synthesized and evaluated for their in vitro antimicrobial and resistance modulating activity against a panel of Gram-positive, Gram-negative, and fungal species.
The compounds were produced in good yields of 60–92% w/w and characterized using melting point, UV-visible spectroscopy, infrared, and nuclear magnetic resonance (1H, 13C, and DEPT-Q) techniques.
Mass spectroscopy was used to confirm the identity of one of the most active compounds, 5 [SA5].
The phenylhydrazones showed activity against all the six selected microorganisms with minimum inhibitory concentration (MIC) values of the most active compounds, 1 [BP1] and 5 [SA5], at 138 µM (Klebsiella pneumoniae) and 165 µM (Streptococcus pneumoniae), respectively.
Compound 1 [BP1] further demonstrated a high resistance modulatory activity at 1.078 µM against Streptococcus pneumoniae and Klebsiella pneumoniae.
American Psychological Association (APA)
Ade, Alberta& Amengor, Cedric D. K.& Brobbey, Abena& Ayensu, Isaac& Harley, Benjamin K.& Boakye, Yaw Duah. 2020. Synthesis and Antimicrobial Resistant Modulatory Activity of 2,4-Dinitrophenylhydrazone Derivatives as Agents against Some ESKAPE Human Pathogens. Journal of Chemistry،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1181529
Modern Language Association (MLA)
Ade, Alberta…[et al.]. Synthesis and Antimicrobial Resistant Modulatory Activity of 2,4-Dinitrophenylhydrazone Derivatives as Agents against Some ESKAPE Human Pathogens. Journal of Chemistry No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1181529
American Medical Association (AMA)
Ade, Alberta& Amengor, Cedric D. K.& Brobbey, Abena& Ayensu, Isaac& Harley, Benjamin K.& Boakye, Yaw Duah. Synthesis and Antimicrobial Resistant Modulatory Activity of 2,4-Dinitrophenylhydrazone Derivatives as Agents against Some ESKAPE Human Pathogens. Journal of Chemistry. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1181529
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181529