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Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of Brazil
Joint Authors
Visentainer, Jeane Eliete Laguila
Ayo, Christiane Maria
Reis, Pâmela Guimarães
Moraes, A. G.
Mazini, Priscila Saamara
Bestetti, Reinaldo Bulgarelli
Macedo, Luciana C.
Sell, Ana M.
Mattos, Luiz Carlos de
Brandão de Mattos, Cinara de Cássia
Sakita, Karina Mayumi
Muller, Larissa Pires
Aquino, Julimary Suematsu
Marques, Divina Seila de Oliveira
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this study was to investigate possible associations between genetic polymorphisms of IL17A G197A (rs2275913) and IL17F T7488C (rs763780) with Chagas Disease (CD) and/or the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas cardiomyopathy (CCC).
The study with 260 patients and 150 controls was conducted in the South and Southeast regions of Brazil.
The genotyping was performed by PCR-RFLP.
The A allele and A/A genotype of IL17A were significantly increased in patients and their subgroups (patients with CCC; patients with CCC and LVSD; and patients with CCC and severe LVSD) when compared to the control group.
The analysis according to the gender showed that the A/A genotype of IL17A was more frequent in female with LVSD and mild to moderate LVSD and also in male patients with LVSD.
The frequency of IL17F T/C genotype was higher in male patients with CCC and severe LVSD and in female with mild to moderate LVSD.
The results suggest the possible involvement of the polymorphisms of IL17A and IL17F in the susceptibility to chronic Chagas disease and in development and progression of cardiomyopathy.
American Psychological Association (APA)
Reis, Pâmela Guimarães& Ayo, Christiane Maria& Mattos, Luiz Carlos de& Brandão de Mattos, Cinara de Cássia& Sakita, Karina Mayumi& Moraes, A. G.…[et al.]. 2017. Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of Brazil. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181535
Modern Language Association (MLA)
Reis, Pâmela Guimarães…[et al.]. Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of Brazil. Journal of Immunology Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1181535
American Medical Association (AMA)
Reis, Pâmela Guimarães& Ayo, Christiane Maria& Mattos, Luiz Carlos de& Brandão de Mattos, Cinara de Cássia& Sakita, Karina Mayumi& Moraes, A. G.…[et al.]. Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of Brazil. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1181535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181535