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Diagnostic and Research Aspects of Small Intestinal Disaccharidases in Coeliac Disease
Joint Authors
Božič, Borut
Šuligoj, Tanja
Ciclitira, Paul J.
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Disaccharidases (DS) are brush border enzymes embedded in the microvillous membrane of small intestinal enterocytes.
In untreated coeliac disease (CD), a general decrease of DS activities is seen.
This manuscript reviews different aspects of DS activities in CD: their utility in the diagnosis and their application to in vitro toxicity testing.
The latter has never been established in CD research.
However, with the recent advances in small intestinal organoid techniques, DS might be employed as a biomarker for in vitro studies.
This includes establishment of self-renewing epithelial cells raised from tissue, which express differentiation markers, including the brush border enzymes.
Determining duodenal DS activities may provide additional information during the diagnostic workup of CD: (i) quantify the severity of the observed histological lesions, (ii) provide predictive values for the grade of mucosal villous atrophy, and (iii) aid diagnosing CD where minor histological changes are seen.
DS can also provide additional information to assess the response to a gluten-free diet as marked increase of their activities occurs four weeks after commencing it.
Various endogenous and exogenous factors affecting DS might also be relevant when considering investigating the role of DS in other conditions including noncoeliac gluten sensitivity and DS deficiencies.
American Psychological Association (APA)
Šuligoj, Tanja& Ciclitira, Paul J.& Božič, Borut. 2017. Diagnostic and Research Aspects of Small Intestinal Disaccharidases in Coeliac Disease. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181538
Modern Language Association (MLA)
Šuligoj, Tanja…[et al.]. Diagnostic and Research Aspects of Small Intestinal Disaccharidases in Coeliac Disease. Journal of Immunology Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1181538
American Medical Association (AMA)
Šuligoj, Tanja& Ciclitira, Paul J.& Božič, Borut. Diagnostic and Research Aspects of Small Intestinal Disaccharidases in Coeliac Disease. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181538
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181538