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Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective
Joint Authors
Chen, Wuzhen
Jiang, Jingxin
Xia, Wenjie
Huang, Jian
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Exosomes are a kind of cell-released membrane-form structures which contain proteins, lipids, and nucleic acids.
These vesicular organelles play a key role in intercellular communication.
Numerous experiments demonstrated that tumor-related exosomes (TEXs) can induce immune surveillance in the microenvironment in vivo and in vitro.
They can interfere with the maturation of DC cells, impair NK cell activation, induce myeloid-derived suppressor cells, and educate macrophages into protumor phenotype.
They can also selectively induce effector T cell apoptosis via Fas/FasL interaction and enhance regulatory T cell proliferation and function by releasing TGF-β.
In this review, we focus on the TEX-induced immunosuppression and microenvironment change.
Based on the truth that TEXs play crucial roles in suppressing the immune system, studies on modification of exosomes as immunotherapy strategies will also be discussed.
American Psychological Association (APA)
Chen, Wuzhen& Jiang, Jingxin& Xia, Wenjie& Huang, Jian. 2017. Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1181551
Modern Language Association (MLA)
Chen, Wuzhen…[et al.]. Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective. Journal of Immunology Research No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1181551
American Medical Association (AMA)
Chen, Wuzhen& Jiang, Jingxin& Xia, Wenjie& Huang, Jian. Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1181551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181551