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A Synthetic Pan-Aurora Kinase Inhibitor, 5-Methoxy-2-(2-methoxynaphthalen-1-yl)-4H-chromen-4-one, Triggers Reactive Oxygen Species-Mediated Apoptosis in HCT116 Colon Cancer Cells
Joint Authors
Shin, Soon Young
Ahn, Seunghyun
Koh, Dongsoo
Lee, Young Han
Lim, Yoongho
Lee, Jeong Yeon
Ahn, Sung Shin
Jeong, You Jeong
Choi, Jihye
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Aurora kinases are Ser/Thr kinases that function as mitotic regulators.
5-Methoxy-2-(2-methoxynaphthalen-1-yl)-4H-chromen-4-one (DK1913) is a synthetic pan-Aurora kinase inhibitor.
However, the mode of action of DK1913 concerning the induction of apoptosis is unclear.
Here, we report that DK1913 triggered apoptosis, as revealed by flow cytometry and Annexin V staining.
DK1913 enhanced the intracellular levels of reactive oxygen species (ROS) and stimulated the endoplasmic reticulum (ER) and genotoxic stress responses.
We also found that DK1913 induced the loss of mitochondrial membrane potential, leading to the activation of caspase-9, caspase-7, and caspase-3.
In addition, the antioxidant, butylated hydroxyanisole (BHA), abrogated DK1913-induced loss of mitochondrial membrane potential and activation of the caspase cascade.
These findings demonstrate that pan-Aurora kinase inhibitor DK1913 triggers apoptosis through ROS-mediated ER and genotoxic stress responses.
American Psychological Association (APA)
Lee, Jeong Yeon& Ahn, Sung Shin& Jeong, You Jeong& Choi, Jihye& Ahn, Seunghyun& Koh, Dongsoo…[et al.]. 2020. A Synthetic Pan-Aurora Kinase Inhibitor, 5-Methoxy-2-(2-methoxynaphthalen-1-yl)-4H-chromen-4-one, Triggers Reactive Oxygen Species-Mediated Apoptosis in HCT116 Colon Cancer Cells. Journal of Chemistry،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1181554
Modern Language Association (MLA)
Lee, Jeong Yeon…[et al.]. A Synthetic Pan-Aurora Kinase Inhibitor, 5-Methoxy-2-(2-methoxynaphthalen-1-yl)-4H-chromen-4-one, Triggers Reactive Oxygen Species-Mediated Apoptosis in HCT116 Colon Cancer Cells. Journal of Chemistry No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1181554
American Medical Association (AMA)
Lee, Jeong Yeon& Ahn, Sung Shin& Jeong, You Jeong& Choi, Jihye& Ahn, Seunghyun& Koh, Dongsoo…[et al.]. A Synthetic Pan-Aurora Kinase Inhibitor, 5-Methoxy-2-(2-methoxynaphthalen-1-yl)-4H-chromen-4-one, Triggers Reactive Oxygen Species-Mediated Apoptosis in HCT116 Colon Cancer Cells. Journal of Chemistry. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1181554
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181554