Regulatory T Cells and Their Prognostic Relevance in Hematologic Malignancies
Joint Authors
Musto, Pellegrino
Vitale, Candida
Coscia, Marta
Festa, Agostino
Laurenti, Luca
Fenoglio, Daniela
D'Arena, Giovanni
De Feo, Vincenzo
Di Minno, Matteo Nicola Dario
Di Minno, Giovanni
Calapai, Gioacchino
Caraglia, Michele
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Regulatory T cells (Tregs) have a fundamental function in monitoring the immune homeostasis in healthy individuals.
In cancer and, in particular, in hematological malignancies, Tregs exert a major immunosuppressive activity, thus playing a critical role in tumor cell growth, proliferation, and survival.
Here, we summarize published data on the prognostic significance of Tregs in hematological malignancies and show that they are highly conflicting.
The heterogeneity of the experimental approaches that were used explains—at least in part—the discordant results reported by different groups that have investigated the role of Tregs in cancer.
In fact, different tissues have been studied (i.e., peripheral blood, bone marrow, and lymph node), applying different methods (i.e., flow cytometry versus immunohistochemistry, whole blood versus isolated peripheral blood mononuclear cells versus depletion of CD25+ cells, various panels of monoclonal antibodies, techniques of fixation and permeabilization, and gating strategies).
This is of relevance in order to stress the need to apply standardized approaches in the study of Tregs in hematological malignancies and in cancer in general.
American Psychological Association (APA)
D'Arena, Giovanni& Vitale, Candida& Coscia, Marta& Festa, Agostino& Di Minno, Matteo Nicola Dario& De Feo, Vincenzo…[et al.]. 2017. Regulatory T Cells and Their Prognostic Relevance in Hematologic Malignancies. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1181592
Modern Language Association (MLA)
D'Arena, Giovanni…[et al.]. Regulatory T Cells and Their Prognostic Relevance in Hematologic Malignancies. Journal of Immunology Research No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1181592
American Medical Association (AMA)
D'Arena, Giovanni& Vitale, Candida& Coscia, Marta& Festa, Agostino& Di Minno, Matteo Nicola Dario& De Feo, Vincenzo…[et al.]. Regulatory T Cells and Their Prognostic Relevance in Hematologic Malignancies. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1181592
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181592