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Effects of Vitamin B6 Deficiency on the Composition and Functional Potential of T Cell Populations
Joint Authors
Qian, Bingjun
Shen, Shanqi
Zhang, Jianhua
Jing, Pu
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The immune system is critical in preventing infection and cancer, and malnutrition can weaken different aspects of the immune system to undermine immunity.
Previous studies suggested that vitamin B6 deficiency could decrease serum antibody production with concomitant increase in IL4 expression.
However, evidence on whether vitamin B6 deficiency would impair immune cell differentiation, cytokines secretion, and signal molecule expression involved in JAK/STAT signaling pathway to regulate immune response remains largely unknown.
The aim of this study is to investigate the effects of vitamin B6 deficiency on the immune system through analysis of T lymphocyte differentiation, IL-2, IL-4, and INF-γ secretion, and SOCS-1 and T-bet gene transcription.
We generated a vitamin B6-deficient mouse model via vitamin B6-depletion diet.
The results showed that vitamin B6 deficiency retards growth, inhibits lymphocyte proliferation, and interferes with its differentiation.
After ConA stimulation, vitamin B6 deficiency led to decrease in IL-2 and increase in IL-4 but had no influence on IFN-γ.
Real-time PCR analysis showed that vitamin B6 deficiency downregulated T-bet and upregulated SOCS-1 transcription.
This study suggested that vitamin B6 deficiency influenced the immunity in organisms.
Meanwhile, the appropriate supplement of vitamin B6 could benefit immunity of the organism.
American Psychological Association (APA)
Qian, Bingjun& Shen, Shanqi& Zhang, Jianhua& Jing, Pu. 2017. Effects of Vitamin B6 Deficiency on the Composition and Functional Potential of T Cell Populations. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181610
Modern Language Association (MLA)
Qian, Bingjun…[et al.]. Effects of Vitamin B6 Deficiency on the Composition and Functional Potential of T Cell Populations. Journal of Immunology Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1181610
American Medical Association (AMA)
Qian, Bingjun& Shen, Shanqi& Zhang, Jianhua& Jing, Pu. Effects of Vitamin B6 Deficiency on the Composition and Functional Potential of T Cell Populations. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1181610
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181610