Folate-Conjugated Chitosan-Pluronic P123 Nanogels: Synthesis and Characterizations towards Dual Drug Delivery
Joint Authors
Tran, Ngoc Quyen
Nguyen, Van Toan
Nguyen, Thi Hương
Dang, Le Hang
Vu-Quang, Hieu
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-21
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
In this study, a self-assembled nanogel-based pluronic P123-grafted chitosan-folate (CP-FA) was fabricated as a paclitaxel/curcumin codelivery system.
1H-NMR and TGA proved that the fabricating method of CP-FA was successful.
Dynamic light scattering (DLS), zeta potentials, and transmission electron microscopy (TEM) exposed that CP-FA nanoparticles had a uniform size with a diameter of around 16.27±2.01 nm in the colloidal solution and had better sustainable stability at a lower concentration than P123 due to the moderate positive potential value (39.43±3.45 mV) and the lower critical micelle concentration (0.036 mg/ml).
Dual drugs were loaded with CP-FA nanogels via self-assembly by the hydrophobic interaction between both hydrophobic therapeutic compounds (PTX and Cur) and the hydrophobic segment of the P123 copolymer.
The high hydrophobicity of the segment induced a great loading efficacy of up to 98.63±0.42 of PTX and 97.82±0.48 of Cur.
In addition, the CP-FA nanogels exposed superior effects in a controlled release of these encapsulated therapeutic compounds for a long period of time.
The anticancer activity of the dual-drug delivery system was evaluated using human breast cancer cell lines (MCF-7) via the IC50 value to compare with the PTX-loading CP-FA nanogel.
The obtained results suggested that CP-FA/PTX-Cur displayed a remarkable improvement in anticancer activity at an IC50 value of 5.74±0.23 nM which was higher than that of CP-FA/PTX (IC50=8.20±1.41 nM) due to the synergistic effect of both PTX and Cur.
Thereby, a dual-drug delivery-system-based CP-FA of PTX and Cur has been proposed as a promising candidate in cancer therapy.
American Psychological Association (APA)
Nguyen, Van Toan& Nguyen, Thi Hương& Dang, Le Hang& Vu-Quang, Hieu& Tran, Ngoc Quyen. 2019. Folate-Conjugated Chitosan-Pluronic P123 Nanogels: Synthesis and Characterizations towards Dual Drug Delivery. Journal of Nanomaterials،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1181619
Modern Language Association (MLA)
Nguyen, Van Toan…[et al.]. Folate-Conjugated Chitosan-Pluronic P123 Nanogels: Synthesis and Characterizations towards Dual Drug Delivery. Journal of Nanomaterials No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1181619
American Medical Association (AMA)
Nguyen, Van Toan& Nguyen, Thi Hương& Dang, Le Hang& Vu-Quang, Hieu& Tran, Ngoc Quyen. Folate-Conjugated Chitosan-Pluronic P123 Nanogels: Synthesis and Characterizations towards Dual Drug Delivery. Journal of Nanomaterials. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1181619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181619